MTCO2 Recombinant Rabbit Monoclonal Antibody [SC06-88] (ET1610-72)

UNIPROT #

P00403

PROTEIN NAME

MTCO2

SYNONYMS

COII antibody;COX2 antibody;COX2_HUMAN antibody;COXII antibody;Cytochrome c oxidase II antibody;Cytochrome c oxidase polypeptide II antibody;Cytochrome c oxidase subunit 2 antibody;MT CO2 antibody;MT-CO2 antibody;MTCO2 antibody

SEQUENCE SIMILARITIES

Belongs to the cytochrome c oxidase subunit 2 family.

SUBCELLULAR LOCATION

Mitochondrion inner membrane.

FUNCTION

Cytochrome c oxidase subunit II (COX2), also designated COII, MTCO2 or oxidative phosphorylation (OxPhos) complex IV, subunit II, is one of three mitochondrial DNA (mtDNA) encoded subunits (MTCO1-3) of respiratory complex IV. Cytochrome c oxidase is a hetero-oligomeric enzyme composed of 13 subunits localized to the mitochondrial inner membrane and is the terminal enzyme complex of the electron transport chain. Complex IV catalyzes the reduction of molecular oxygen to water. The energy released is used to transport protons across the mitochondrial inner membrane. The resulting electrochemical gradient is necessary for the synthesis of ATP. Complex IV contains 13 polypeptides; COX1, COX2 and COX3 (MTCO1-3) make up the catalytic core and are encoded by mtDNA while subunits IV, Va, Vb, VIa, VIb, VIc, VIIa, VIIb, VIIc and VIII are nuclear-encoded. Defects in COX2 are associated with tumor formation.