NPY2R / Y2 receptor Rabbit Polyclonal Antibody (ER1901-14)

UNIPROT #

P49146

PROTEIN NAME

NPY2R / Y2 receptor

SYNONYMS

Neuropeptide Y receptor type 2 antibody;Neuropeptide Y receptor Y2 antibody;NPY-Y2 receptor antibody;NPY2-R antibody;NPY2R antibody;NPY2R_HUMAN antibody;Y2 receptor antibody

SEQUENCE SIMILARITIES

Belongs to the G-protein coupled receptor 1 family.

TISSUE SPECIFICITY

High levels in amygdala, corpus callosum, hippocampus and subthalamic nucleus. Also detectable in caudate nucleus, hypothalamus and substantia nigra.

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

Neuropeptide Y (NPY) and its family of five receptors are known to be associated with hypothalamic regulation of feeding behavior, metabolism, and energy homeostasis in both rodents and humans. In particular, knock-out mice for the gene neuropeptide Y 2 receptor, NPY2R, exhibit hyperphagia and excessive weight gain. As a result, research on the gene has focused on genotyping analysis for the identification of single nucleotide polymorphisms (SNPs) in obese human subjects and drug development for manipulation of its expression as a novel therapeutic treatment for obesity. Although primarily expressed in the arcuate nucleus of the hypothalamus, NPY2R may also be found in other tissues including trabecular bone, vascular tissue, and colonic mucosa.