CD73 Rabbit Polyclonal Antibody (R1107-6)

UNIPROT #

P21589

PROTEIN NAME

CD73

SYNONYMS

5' NT antibody;5' nucleotidase (CD73) antibody;5' nucleotidase precursor antibody;5' nucleotidase, ecto antibody;5' nucleotidase, ecto (CD73) antibody;5'-NT antibody;5'-nucleotidase antibody;5NTD_HUMAN antibody;CD73 antibody;CD73 antigen antibody;E5NT antibody;Ecto 5' nucleotidase antibody;Ecto-5'-nucleotidase antibody;eN antibody;eNT antibody;NT antibody;NT5 antibody;NT5E antibody;NTE antibody;Purine 5 Prime Nucleotidase antibody

SEQUENCE SIMILARITIES

Belongs to the 5'-nucleotidase family.

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

CD73 (also designated ecto-5'-nucleotidase, E5NT, NT, NT5, NTE, eN and eNT) is a glycosyl-phosphatidylinositol (GPI)-anchored adhesion protein that catalyzes the dephosphorylation of extracellular purine and pyrimidine nucleotides to their corresponding bioactive nucleosides. CD73 is a dimer of two identical subunits that depends on GPI to link with the external face of the plasma membrane. Similar to other GPI-anchored proteins, CD73 mediates co-stimulatory signals in T cell activation. CD73 has few structural variants, yet elicits diverse biological function through differential regulation in endothelial cells (EC), subpopulations of B and T cells, germinal center follicular dendritic cells and on thymic medullary reticular fibroblasts. For example, IgG mediated neutralization of CD73 interferes with lymphocyte adhesion to EC, and blocks aggregation of germinal center B cells and follicular dendritic cells. Furthermore, IgG-mediated targeting of lymphocyte CD73, but not of endothelial cell CD73, causes shedding of CD73 and tyrosine phosphorylation of proteins.