Glycophorin A Rabbit Polyclonal Antibody (0806-7)

UNIPROT #

P02724

PROTEIN NAME

Glycophorin A

SYNONYMS

AI853584 antibody;Blood group--MN locus antibody;CD_antigen=CD235a antibody;CD235a antibody;GLPA_HUMAN antibody;Glycophorin A (MNS blood group) antibody;Glycophorin A antibody;Glycophorin A, included antibody;Glycophorin-A antibody;GlycophorinA antibody;GPA antibody;GPErik antibody;GpMiIII antibody;GPSAT antibody;GYPA antibody;GYPA, included antibody;HGpMiIII antibody;HGpMiV antibody;HGpMiX antibody;HGpMiXI antibody;HGpSta(C) antibody;MN antibody;MN sialoglycoprotein antibody;MNS antibody;PAS-2 antibody;PAS2 antibody;Sialoglycoprotein alpha antibody

SEQUENCE SIMILARITIES

Belongs to the glycophorin A family.

POST-TRANSLATIONAL MODIFICATION

The major O-linked glycan are NeuAc-alpha-(2-3)-Gal-beta-(1-3)-[NeuAc-alpha-(2-6)]-GalNAcOH (about 78 %) and NeuAc-alpha-(2-3)-Gal-beta-(1-3)-GalNAcOH (17 %). Minor O-glycans (5 %) include NeuAc-alpha-(2-3)-Gal-beta-(1-3)-[NeuAc-alpha-(2-6)]-GalNAcOH NeuAc-alpha-(2-8)-NeuAc-alpha-(2-3)-Gal-beta-(1-3)-GalNAcOH. About 1% of all O-linked glycans carry blood group A, B and H determinants. They derive from a type-2 precursor core structure, Gal-beta-(1,3)-GlcNAc-beta-1-R, and the antigens are synthesized by addition of fucose (H antigen-specific) and then N-acetylgalactosamine (A antigen-specific) or galactose (B antigen-specific). Specifically O-linked-glycans are NeuAc-alpha-(2-3)-Gal-beta-(1-3)-GalNAcOH-(6-1)-GlcNAc-beta-(4-1)-[Fuc-alpha-(1-2)]-Gal-beta-(3-1)-GalNAc-alpha (about 1%, B antigen-specific) and NeuAc-alpha-(2-3)-Gal-beta-(1-3)-GalNAcOH-(6-1)-GlcNAc-beta-(4-1)-[Fuc-alpha-(1-2)]-Gal-beta (1 %, O antigen-, A antigen- and B antigen-specific).

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. Is a receptor for influenza virus. Is a receptor for Plasmodium falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. Appears to be a receptor for Hepatitis A virus (HAV).