ACE2 Rabbit Polyclonal Antibody (ER1902-40)

UNIPROT #

Q9BYF1

PROTEIN NAME

ACE2

SYNONYMS

ACE 2 antibody;ACE related carboxypeptidase antibody;ACE-related carboxypeptidase antibody;ACE2 antibody;ACE2_HUMAN antibody;ACEH antibody;Angiotensin converting enzyme 2 antibody;Angiotensin converting enzyme homolog antibody;Angiotensin converting enzyme like protein antibody;Angiotensin I Converting Enzyme (peptidyl dipeptidase A) 2 antibody;Angiotensin I converting enzyme 2 antibody;Angiotensin-converting enzyme homolog antibody;DKFZP434A014 antibody;EC 3.4.17 antibody;metalloprotease MPROT 15 antibody;Metalloprotease MPROT15 antibody;OTTHUMP00000022963 antibody

SEQUENCE SIMILARITIES

Belongs to the peptidase M2 family.

TISSUE SPECIFICITY

Expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells (at protein level). Expressed in lung alveolar epithelial cells, enterocytes of the small intestine, Leydig cells and Sertoli cells (at protein level). Expressed in the renal proximal tubule and the small intestine (at protein level). Expressed in heart, kidney, testis, and gastrointestinal system.

POST-TRANSLATIONAL MODIFICATION

N-glycosylation on Asn-90 may limit SARS infectivity.; Proteolytic cleavage by ADAM17 generates a secreted form. Also cleaved by serine proteases: TMPRSS2, TMPRSS11D and HPN/TMPRSS1.

SUBCELLULAR LOCATION

Secreted, Cell membrane.

FUNCTION

Angiotensin-converting enzyme (ACE) is a carboxyl-terminal dipeptidyl exopeptidase that converts angiotensin I to the potent vasopressive hormone, angiotensin II. There are two isoforms of ACE, the pulmonary ACEP and the testicular ACET. ACEP is a glycoprotein expressed in vascular endothelial cells of the lung, liver, adrenal cortex, pancreas, kidney and spleen. The ACET isoform is expressed exclusively in adult testis by developing sperm cells, specifically late pachytene spermatocytes. Additionally, ACE inactivates bradykinin, a vasodepressor peptide, and is involved in blood pressure regulation and fluid/electrolyte homeostasis. ACE2 is the first known human homolog of ACE. Unlike ACE, which is expressed ubiquitously throughout the vasculature, ACE2 is expressed only in cardiac, renal and testicular cells. ACE2 is not sensitive to the ACE inhibitor drugs used to treat hypertension. ACE2 receptors have been shown to be the entry point into human cells for some coronaviruses, including the SARS virus[10]. A number of studies have identified that the entry point is the same for SARS-CoV-2, the COVID-19 virus.