GNB3 Rabbit Polyclonal Antibody (HA500153)

UNIPROT #

P16520

PROTEIN NAME

GNB3

SYNONYMS

G protein beta 3 subunit antibody;GBB3_HUMAN antibody;GNB3 antibody;GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3 antibody;GTP binding regulatory protein beta 3 chain antibody;Guanine nucleotide binding protein (G protein) beta polypeptide 3 antibody;Guanine nucleotide binding protein G antibody;Guanine nucleotide binding protein G(I)/G(S)/G(T) beta subunit 3 antibody;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 antibody;Hypertension associated protein antibody;IG antibody;SG antibody;Transducin beta chain 3 antibody;Tsubunit beta 3 antibody

SUBCELLULAR LOCATION

Cytosol.

FUNCTION

Heterotrimeric guanine nucleotide-binding proteins ( G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Additional splice variants may exist for this gene, but they have not been fully described.