Kininogen 1 Recombinant Rabbit Monoclonal Antibody [JE43-72] (ET7109-34)

UNIPROT #

P01042

PROTEIN NAME

Kininogen 1

SYNONYMS

Alpha-2-thiol proteinase inhibitor antibody;BDK antibody;BK antibody;Bradykinin antibody;Bradykinin included antibody;Fitzgerald factor antibody;FLAUJEAC FACTOR antibody;High molecular weight kininogen antibody;HMWK antibody;Ile-Ser-Bradykinin antibody;Kallidin I antibody;Kallidin II antibody;KNG antibody;KNG1 antibody;KNG1_HUMAN antibody;Low molecular weight growth-promoting factor antibody;WILLIAMS FACTOR antibody;Williams-Fitzgerald-Flaujeac factor antibody

TISSUE SPECIFICITY

Secreted in plasma. T-kinin is detected in malignant ovarian, colon and breast carcinomas, but not in benign tumors.

POST-TRANSLATIONAL MODIFICATION

Bradykinin is released from kininogen by plasma kallikrein.; Hydroxylation of Pro-383 occurs prior to the release of bradykinin.; Phosphorylated by FAM20C in the extracellular medium.; N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Kininogen-1 (KNG1), also known as alpha-2-thiol proteinase inhibitor, Williams-Fitzgerald-Flaujeac factor or the HMWK-kallikrein factor is a protein that in humans is encoded by the KNG1 gene. Kininogen-1 is the precursor protein to high-molecular-weight kininogen (HMWK), low-molecular-weight kininogen (LMWK), and bradykinin. The KNG1 gene uses alternative splicing to generate two different proteins: high-molecular-weight kininogen (HMWK) and low-molecular-weight kininogen (LMWK). HMWK in turn is cleaved by the enzyme kallikrein to produce bradykinin. HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. In contrast to HMWK, LMWK is not involved in blood coagulation. Kininogen-1 is a constituent of the blood coagulation system as well as the kinin-kallikrein system.