PER2 Recombinant Rabbit Monoclonal Antibody [JE33-79] (HA721036)

UNIPROT #

O15055

PROTEIN NAME

PER2

SYNONYMS

Circadian clock protein PERIOD 2 antibody;FASPS antibody;FASPS1 antibody;hPER 2 antibody;hPER2 antibody;KIAA0347 antibody;OTTHUMP00000164476 antibody;PER 2 antibody;PER2 antibody;PER2_HUMAN antibody;Period 2 antibody;Period 2 isoform 1 antibody;Period circadian clock 2 antibody;Period circadian protein 2 antibody;Period circadian protein homolog 2 antibody;Period homolog 2 (Drosophila) antibody;Period homolog 2 antibody;Period, Drosophila, homolog of, 2 antibody;Period2 antibody

SUBCELLULAR LOCATION

Nucleus, Cytoplasm, Perinuclear region; Nucleolus.

FUNCTION

This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers and have been linked to sleep disorders. Controls circadian glutamate uptake in synaptic vesicles through the regulation of VGLUT1 expression. May also be involved in the regulation of inflammatory processes. Represses the CLOCK-ARNTL/BMAL1 induced transcription of BHLHE40/DEC1 and ATF4. Negatively regulates the formation of the TIMELESS-CRY1 complex by competing with TIMELESS for binding to CRY1.