SERPINC1 Rabbit Polyclonal Antibody (ER1803-06)

UNIPROT #

P01008

PROTEIN NAME

SERPINC1

SYNONYMS

ANT3_HUMAN antibody;Antithrombin antibody;Antithrombin III antibody;Antithrombin-III antibody;AntithrombinIII antibody;AT 3 antibody;AT III antibody;AT3 antibody;AT3D antibody;ATIII antibody;Heparin cofactor I antibody;MGC22579 antibody;Serine (or cysteine) proteinase inhibitor clade C (antithrombin) member 1 antibody;Serine cysteine proteinase inhibitor clade C member 1 antibody;Serine proteinase inhibitor clade C member 1 antibody;Serpin C1 antibody;Serpin family C member 1 antibody;Serpin peptidase inhibitor clade C (antithrombin) member 1 antibody;SERPINC1 antibody;THPH7 antibody

SEQUENCE SIMILARITIES

Belongs to the serpin family.

TISSUE SPECIFICITY

Found in plasma.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated by FAM20C in the extracellular medium.

SUBCELLULAR LOCATION

Secreted.

FUNCTION

The serine proteinase inhibitors (serpins) compose a superfamily of proteins with a diverse set of functions, including the control of blood coagulation, complement activation, programmed cell death and development. Serpins are secreted glycoproteins that contain a stretch of peptide that mimics a true substrate for a corresponding serine protease. Antithrombin III (ATIII), an extracellular plasma protein, is a crucial serine protease inhibitor that regulates the coagulation cascade in blood. The inhibitory activity of ATIII is amplified in the presence of heparin. ATIII inhibits Thrombin and Factors IXa, Xa and XIa. Defects in the gene SERPINC1, which encodes for ATIII, can cause ATIII deficiency, an autosomal dominant disease which is a risk factor for hereditary thrombophilia.