PAI1 Rabbit Polyclonal Antibody (HA500124)

UNIPROT #

P05121

PROTEIN NAME

PAI1

SYNONYMS

Clade E antibody;Endothelial plasminogen activator inhibitor antibody;Nexin antibody;Nexin plasminogen activator inhibitor type 1 antibody;PAI 1 antibody;PAI antibody;PAI-1 antibody;PAI1_HUMAN antibody;PLANH1 antibody;Plasminogen activator inhibitor 1 antibody;Plasminogen activator inhibitor type 1 antibody;Serine (or cysteine) proteinase inhibitor antibody;Serine (or cysteine) proteinase inhibitor clade E (nexin plasminogen activator inhibitor type 1) member 1 antibody;Serine proteinase inhibitor clade E member 1 antibody;serpin antibody;Serpin E1 antibody;Serpin peptidase inhibitor clade E (nexin plasminogen activator inhibitor type 1) member 1 antibody;Serpin peptidase inhibitor clade E antibody;Serpine 1 antibody;SERPINE1 antibody

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair). It is involved in cellular and replicative senescence. Plays a role in alveolar type 2 cells senescence in the lung. Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.