PLAU Rabbit Polyclonal Antibody (HA500429)

UNIPROT #

P00749

PROTEIN NAME

PLAU

SYNONYMS

ATF antibody;ATF uPA antibody;BDPLT5 antibody;Plasminogen activator antibody;Plasminogen activator urinary antibody;Plasminogen activator urokinase antibody;PLAU antibody;QPD antibody;u PA antibody;U plasminogen activator antibody;u-PA antibody;U-plasminogen activator antibody;uPA antibody;URK antibody;UROK_HUMAN antibody;Urokinase plasminogen activator antibody;Urokinase type plasminogen activator antibody;Urokinase type plasminogen activator precursor antibody;Urokinase-type plasminogen activator chain B antibody;hide

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Urokinase, also known as urokinase-type plasminogen activator (uPA), is a serine protease present in humans and other animals. The human urokinase protein was discovered, but not named, by McFarlane and Pilling in 1947. Urokinase was originally isolated from human urine, and it is also present in the blood and in the extracellular matrix of many tissues. The primary physiological substrate of this enzyme is plasminogen, which is an inactive form (zymogen) of the serine protease plasmin. Activation of plasmin triggers a proteolytic cascade that, depending on the physiological environment, participates in thrombolysis or extracellular matrix degradation. This cascade had been involved in vascular diseases and cancer progression. Urokinase is encoded in humans by the PLAU gene, which stands for "plasminogen activator, urokinase". The same symbol represents the gene in other animal species.