Urokinase Recombinant Rabbit Monoclonal Antibody [JM106-09] (ET1703-26)

UNIPROT #

P00749

PROTEIN NAME

Urokinase

SYNONYMS

ATF antibody;ATF uPA antibody;BDPLT5 antibody;Plasminogen activator antibody;Plasminogen activator urinary antibody;Plasminogen activator urokinase antibody;PLAU antibody;QPD antibody;u PA antibody;U plasminogen activator antibody;u-PA antibody;U-plasminogen activator antibody;uPA antibody;URK antibody;UROK_HUMAN antibody;Urokinase plasminogen activator antibody;Urokinase type plasminogen activator antibody;Urokinase type plasminogen activator precursor antibody;Urokinase-type plasminogen activator chain B antibody

SEQUENCE SIMILARITIES

Belongs to the peptidase S1 family.

TISSUE SPECIFICITY

Expressed in the prostate gland and prostate cancers.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation of Ser-158 and Ser-323 abolishes proadhesive ability but does not interfere with receptor binding.

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Urokinase, also known as urokinase-type plasminogen activator (uPA), is a serine protease present in humans and other animals. Urokinase was originally isolated from human urine, and it is also present in the blood and in the extracellular matrix of many tissues. The primary physiological substrate of this enzyme is plasminogen, which is an inactive form (zymogen) of the serine protease plasmin. Activation of plasmin triggers a proteolytic cascade that, depending on the physiological environment, participates in thrombolysis or extracellular matrix degradation. This cascade had been involved in vascular diseases and cancer progression.