ACO1 Rabbit Polyclonal Antibody (R1512-16)

UNIPROT #

P21399

PROTEIN NAME

ACO1

SYNONYMS

ACO 1 antibody;ACO1 antibody;ACOC_HUMAN antibody;Aconitase 1 soluble antibody;Aconitase antibody;Aconitase1 antibody;Aconitate hydratase antibody;ACONS antibody;Citrate hydro lyase antibody;Citrate hydro-lyase antibody;Cytoplasmic aconitate hydratase antibody;Ferritin repressor protein antibody;IRE BP 1 antibody;IRE-BP 1 antibody;IREB 1 antibody;IREB1 antibody;IREBP antibody;IREBP1 antibody;Iron regulatory protein 1 antibody;Iron responsive element binding protein 1 antibody;Iron-responsive element-binding protein 1 antibody IRP 1 antibody;IRP1 antibody;OTTHUMP00000045233 antibody

SEQUENCE SIMILARITIES

Belongs to the aconitase/IPM isomerase family.

SUBCELLULAR LOCATION

Cytoplasm, cytosol.

FUNCTION

Iron metabolism is essential for sustaining mammalian homeostasis. Iron uptake and distribution is a highly regulated process in mammalian cells that is monitored by two iron sensing proteins; iron regulatory protein-1 and -2 (IRP-1 and -2), also known as iron responsive element-binding protein-1 and -2 (IRE-BP-1 and -2) or aconitase 1 and 2. IRP-1 and IRP-2 are important soluble regulatory factors that mediate iron uptake and storage in mammalian cells. They are capable of either repressing translation or enhancing mRNA stability by associating with stem-loop motifs known as iron-responsive elements (IREs). IRPs respond to stress mediators, iron concentration and signaling factors, including nitrogen monoxide, cytokines and hydrogen peroxide.