PGK1 Recombinant Rabbit Monoclonal Antibody [ST49-07] (ET1609-63)

UNIPROT #

P00558

PROTEIN NAME

PGK1

SYNONYMS

Cell migration-inducing gene 10 protein antibody;Epididymis secretory sperm binding protein Li 68p antibody;HEL S 68p antibody;MGC117307 antibody;MGC8947 antibody;MIG10 antibody;pgk1 antibody;PGK1_HUMAN antibody;PGKA antibody;Phosphoglycerate kinase 1 antibody;Primer recognition protein 2 antibody;PRP 2 antibody

SEQUENCE SIMILARITIES

Belongs to the phosphoglycerate kinase family.

TISSUE SPECIFICITY

Mainly expressed in spermatogonia. Localized on the principle piece in the sperm (at protein level). Expression significantly decreased in the testis of elderly men.

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

Phosphoglycerate kinases 1/2 (PGK1/2, ATP:3-phospho-D-glycerate 1-phosphotransferase, EC 2.7.2.3) are somatically expressed, glycolytic enzymes that catalyze the transfer of a phosphoryl group from the acyl phosphate of 1,3-bisphosphoglycerate to ADP, thereby forming ATP and 3-phosphoglycerate. The human PGK gene is interrupted by 10 introns and spans 23 kilobases, and is X chromosome-linked at position Xq21.1, a region implicated in prostate cancer, androgen insensitivity, perineal hypospadias, and other genetic abnormalities. In addition to influencing glycolysis, the PGK1 is secreted by tumor cells and contributes to proliferative angiogenic processes as a disulfide reductase. PGK1 mediated reduction of disulphide bonds in the serine proteinase plasmin initiates the release of the tumor blood vessel inhibitor angiostatin, an event that is critical for blood vessel formation or angiogenesis in tumor expansion and metastasis.