Transferrin Receptor 2 Recombinant Rabbit Monoclonal Antibody [JG58-34] (ET7108-21)

UNIPROT #

Q9UP52

PROTEIN NAME

Transferrin Receptor 2

SYNONYMS

HFE 3 antibody;HFE3 antibody;MGC126368 antibody;TFR 2 antibody;TfR2 antibody;TFR2_HUMAN antibody;TFRC 2 antibody;TFRC2 antibody;Transferrin receptor 2 antibody;Transferrin receptor protein 2 antibody

SEQUENCE SIMILARITIES

Belongs to the peptidase M28 family. M28B subfamily.

TISSUE SPECIFICITY

Predominantly expressed in liver. While the alpha form is also expressed in spleen, lung, muscle, prostate and peripheral blood mononuclear cells, the beta form is expressed in all tissues tested, albeit weakly.

SUBCELLULAR LOCATION

Cell membrane. Cytoplasm.

FUNCTION

Iron is a vital molecule for living organisms because it is involved in a wide variety of metabolic processes, such as oxygen transport, DNA synthesis and electron transport. Excessive iron uptake leads to tissue damage as a result of formation of free radicals. Iron uptake and storage is tightly regulated by the feedback system of iron responsive element-containing gene products and iron regulatory proteins that modulate the expression levels of the genes involved in iron metabolism. The transferrin receptor 2 (TFR2) mediates the uptake of transferrin-bound iron. It is involved in iron metabolism, hepatocyte function and erythrocyte differentiation, and is highly expressed as a protein in liver as well as in hepatocytes and erythroid precursors. The gene encoding human TRF2 maps to chromosome 7q22 and is expressed as an a isoform, which encodes a transmembrane protein, and a b isoform, which encodes a shorter, intracellular protein. Mutations in the TFR2 gene result in hereditary hemochromatosis type III (HFE3), an iron overloading disorder that results in clinical complications, including cirrhosis, cardiopathy, diabetes, endocrine dysfunctions, arthropathy and susceptibility to liver cancer.