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CD31 Rabbit Polyclonal Antibody (ER31219)

Price: Regular price $315.00

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Catalog# ER31219

Rabbit Polyclonal to CD31

Tested for

  • WB

  • IF-Cell

  • FC

  • IHC-P

Reacts with

  • Human

  • Mouse

  • Rat

This product has been cited in peer reviewed publications, see list HERE

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Specifications

Product Type

Rabbit polyclonal primary

Product Name

CD31 Rabbit Polyclonal Antibody (ER31219)

Immunogen

Synthetic peptide within c-terminal residues of cd31.

Host

Rabbit

Positive Control

THP-1 cell lysate, Mouse lung tissue lysate, Rat lung tissue lysate, human lung tissue, human tonsil tissue, rat lung tissue, Hela, HUVEC, NIH/3T3, SW480, Jurkat.

Conjugation

Unconjugated

Clonality

Polyclonal

RRID

AB_3069567

APPLICATION DILUTION

  • WB

  • 1:1,000

  • IF-Cell

  • 1:200

  • FC

  • 1:100-1:200

  • IHC-P

  • 1:1,000-1:5,000

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Immunogen affinity purified.

Molecular Weight

Predicted band size: 83 kDa

Isotype

IgG

TARGET

UNIPROT #

P16284

PROTEIN NAME

CD31

SYNONYMS

Adhesion molecule antibody;CD31 antibody;CD31 antigen antibody;CD31 EndoCAM antibody;EndoCAM antibody;FLJ34100 antibody;FLJ58394 antibody;GPIIA antibody;GPIIA' antibody;PECA1 antibody;PECA1_HUMAN antibody;Pecam 1 antibody;PECAM 1 CD31 EndoCAM antibody;PECAM antibody;PECAM-1 antibody;Pecam1 antibody;Platelet and endothelial cell adhesion molecule 1 antibody;Platelet endothelial cell adhesion molecule antibody;Platelet/endothelial cell adhesion molecule 1 antibody

TISSUE SPECIFICITY

Expressed on platelets and leukocytes and is primarily concentrated at the borders between endothelial cells. Expressed in human umbilical vein endothelial cells (HUVECs) (at protein level). Expressed on neutrophils (at protein level). Isoform Long predominates in all tissues examined. Isoform Delta12 is detected only in trachea. Isoform Delta14-15 is only detected in lung. Isoform Delta14 is detected in all tissues examined with the strongest expression in heart. Isoform Delta15 is expressed in brain, testis, ovary, cell surface of platelets, human umbilical vein endothelial cells (HUVECs), Jurkat T-cell leukemia, human erythroleukemia (HEL) and U-937 histiocytic lymphoma cell lines (at protein level).

POST-TRANSLATIONAL MODIFICATION

Phosphorylated on Ser and Tyr residues after cellular activation by src kinases. Upon activation, phosphorylated on Ser-729 which probably initiates the dissociation of the membrane-interaction segment (residues 709-729) from the cell membrane allowing the sequential phosphorylation of Tyr-713 and Tyr-690. Constitutively phosphorylated on Ser-734 in resting platelets. Phosphorylated on tyrosine residues by FER and FES in response to FCER1 activation (By similarity). In endothelial cells Fyn mediates mechanical-force (stretch or pull) induced tyrosine phosphorylation.; Palmitoylation by ZDHHC21 is necessary for cell surface expression in endothelial cells and enrichment in membrane rafts.

SUBCELLULAR LOCATION

Cell membrane, Cell junction.

FUNCTION

PECAM-1 is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte transmigration, angiogenesis, and integrin activation. CD31 is also expressed in certain tumors, including epithelioid hemangioendothelioma, epithelioid sarcoma-like hemangioendothelioma, other vascular tumors, histiocytic malignancies, and plasmacytomas. It is rarely found in some sarcomas, such as Kaposi's sarcoma and carcinomas. In immunohistochemistry, CD31 is used primarily to demonstrate the presence of endothelial cells in histological tissue sections. This can help to evaluate the degree of tumour angiogenesis, which can imply a rapidly growing tumor

CITATIONS

  • VEGF-Modified PVA/Silicone Nanofibers Enhance Islet Function Transplanted in Subcutaneous Site Followed by Device-Less Procedure

  • Zhenyu Wang,et al

    Morphology-Mediated Tumor Deep Penetration for Enhanced Near Infrared II Photothermal and Chemotherapy of Colorectal Cancer

  • Xu, F., Zhang, J., Ji, L., Cui, W., Cui, J., Tang, Z., Sun, N., Zhang, G., Guo, M., Liu, B., & Dong, J.

    Inhibition of Non-small Cell Lung Cancer by Ferroptosis and Apoptosis Induction through P53 and GSK-3β/Nrf2 Signal Pathways using Qingrehuoxue Formula

  • Ze-Qi decoction inhibits non-small cell lung cancer growth and metastasis by modulating the PI3K/Akt/p53 signaling pathway

  • Wanshun Wang,et al

    Microenvironment-responsive injectable hydrogel for neuro-vascularized bone regeneration

  • Heng Liu,et al

    RVG-peptide-camouflaged iron-coordinated engineered polydopamine nanoenzyme with ROS scavenging and inhibiting inflammatory response for ischemic stroke therapy

  • Kindlin-2 controls angiogenesis through modulating Notch1 signaling

  • Li, H., Song, D., Liu, Q., Li, L., Sun, X., Guo, J., Li, D., & Li, P.

    miR-351 promotes atherosclerosis in diabetes by inhibiting the ITGB3/PIK3R1/Akt pathway and induces endothelial cell injury and lipid accumulation

  • Qin, Y., Wu, G., Jin, J., Wang, H., Zhang, J., Liu, L., Zhao, H., Wang, J., & Yang, X.

    A fully human connective tissue growth factor blocking monoclonal antibody ameliorates experimental rheumatoid arthritis through inhibiting angiogenesis

  • TBX20 Contributes to Balancing the Differentiation of Perivascular Adipose-Derived Stem Cells to Vascular Lineages and Neointimal Hyperplasia

  • Li Xiaomei,et al

    Application of Bletilla striata polysaccharide hydrogel for wound healing among in diabetes

  • Effect of Nintedanib Nanothermoreversible Hydrogel on Neovascularization in an Ocular Alkali Burn Rat Model

  • Luo Zhenyu,et al

    Multifunctional and immunoregulatory microenvironment-responsive hydrogel for whole course management of infected diabetic wounds

  • Yang, R. C., Huang, K., Zhang, H. P., Li, L., Zhang, Y. F., Tan, C., Chen, H. C., Jin, M. L., & Wang, X. R.

    SARS-CoV-2 productively infects human brain microvascular endothelial cells

  • A fully human monoclonal antibody targeting Semaphorin 5A alleviates the progression of rheumatoid arthritis

  • Xiangchen Su,et al

    Microenvironmental pH modulating oxygen self-boosting microalgal prodrug carboxymethyl chitosan/hyaluronic acid/puerarin hydrogel for accelerating wound healing in diabetic rats

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