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CD42b Rabbit Polyclonal Antibody (ER1803-26)

Price: Regular price $315.00

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Catalog# ER1803-26

Rabbit Polyclonal to CD42b

Tested for

  • WB

  • IF-Cell

  • IHC-P

  • FC

Reacts with

  • Human

Safety datasheet

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Specifications

Product Type

Rabbit polyclonal primary

Product Name

CD42b Rabbit Polyclonal Antibody (ER1803-26)

Immunogen

Recombinant protein within human cd42b aa 117-328 / 652.

Host

Rabbit

Positive Control

Jurkat, human spleen tissue.

Conjugation

Unconjugated

Clonality

Polyclonal

RRID

AB_3069224

APPLICATION DILUTION

  • IF-Cell

  • 1:50-1:200

  • IHC-P

  • 1:50-1:200

  • FC

  • 1:50-1:100

  • WB

  • 1:500

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Immunogen affinity purified.

Molecular Weight

Predicted band size: 71 kDa

Isotype

IgG

TARGET

UNIPROT #

P07359

PROTEIN NAME

CD42b

SYNONYMS

Antigen CD42b alpha antibody;BDPLT1 antibody;BDPLT3 antibody;BSS antibody;CD 42b antibody;CD42b alpha antibody;CD42B antibody;CD42b antigen antibody;DBPLT3 antibody;GLYCOCALICIN antibody;Glycoprotein Ib (platelet) alpha polypeptide antibody;Glycoprotein Ibalpha antibody;GP Ib alpha antibody;GP1B antibody;GP1BA antibody;GPIb alpha antibody;GPIbA antibody;MGC34595 antibody;Platelet glycoprotein Ib alpha chain antibody;Platelet glycoprotein Ib alpha polypeptide antibody;Platelet membrane glycoprotein 1b alpha subunit antibody;VWDP antibody

POST-TRANSLATIONAL MODIFICATION

Glycocalicin is the product of a proteolytic cleavage/shedding, catalyzed by ADAM17, which releases most of the extracellular domain. Binding sites for vWF and thrombin are in this part of the protein.

SUBCELLULAR LOCATION

Membrane. Secreted.

FUNCTION

CD42a is a single-chain membrane glycoprotein that forms a noncovalent complex with CD42b. CD42b, also known as glycoprotein Ib a (GPIb a) is a membrane glycoprotein that is composed of a and b chains. The CD42b b chain is also designated CD42c, and is expressed on platelets and megakaryocytes. CD42a and CD42b are also present on platelets and mega-karyocytes, and the complex is a major component of the platelet surface. The complex acts as a receptor for von Willebrand's factor and as a von Willebrand's factor-dependent adhesion receptor.

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