SIRT3 Rabbit Polyclonal Antibody (R1511-3)

UNIPROT #

Q9NTG7

PROTEIN NAME

SIRT3

SYNONYMS

hSIRT 3 antibody;hSIRT3 antibody;Mitochondrial nicotinamide adenine dinucleotide dependent deacetylase antibody;NAD dependent deacetylase sirtuin 3 mitochondrial antibody;NAD-dependent protein deacetylase sirtuin-3, mitochondrial antibody;Regulatory protein SIR2 homolog 3 antibody;Silent mating type information regulation 2 S.cerevisiae homolog 3 antibody;Sir 2 like 3 antibody;SIR 2 like protein 3 antibody;SIR 3 antibody;SIR2 L3 antibody;Sir2 like 3 antibody;SIR2 like protein 3 antibody;SIR2-like protein 3 antibody;SIR2L3 antibody;SIR3_HUMAN antibody;SIRT 3 antibody;SIRT3 antibody;Sirtuin 3 antibody;Sirtuin silent mating type information regulation 2 homolog 3 (S. cerevisiae) antibody;Sirtuin type 3 antibody;Sirtuin3 antibody

SEQUENCE SIMILARITIES

Belongs to the sirtuin family. Class I subfamily.

TISSUE SPECIFICITY

Widely expressed.

POST-TRANSLATIONAL MODIFICATION

Processed by mitochondrial processing peptidase (MPP) to give a 28 kDa product. Such processing is probably essential for its enzymatic activity.

SUBCELLULAR LOCATION

Mitochondrion matrix

FUNCTION

The Silent Information Regulator (SIR2) family of genes are highly conserved from prokaryotes to eukaryotes and are involved in diverse processes, including transcriptional regulation, cell cycle progression, DNA-damage repair and aging. In S. cerevisiae, Sir2p deacetylates histones in an NAD-dependent manner, which regulates silencing at the telomeric, rDNA and silent mating-type loci. Sir2p is the founding member of a large family, designated sirtuins, which contain a conserved catalytic domain. The human homologues, which include SIRT1-7, are divided into four main branches: SIRT1-3 are class I, SIRT4 is class II, SIRT5 is class III and SIRT6-7 are class IV. SIRT3 is a NAD-dependent deacetylase that contains one deacetylase sirtuin-type domain. The SIRT3 protein is widely expressed and localizes to the mitochondira where it is processed by mitochondrial processing peptidase (MPP) to yield a final product. This processing is most-likely necessary for its enzymatic activity.