Phospho-SQSTM1 / p62 (S349) Recombinant Rabbit Monoclonal Antibody [PSH08-97] (HA723050)

UNIPROT #

Q13501

PROTEIN NAME

Phospho-SQSTM1 / p62 (S349)

SYNONYMS

A170 antibody;DMRV antibody;EBI 3 associated protein of 60 kDa antibody;EBI 3 associated protein p60 antibody;EBI3 associated protein of 60 kDa antibody;EBI3 associated protein p60 antibody;EBI3-associated protein of 60 kDa antibody;EBIAP antibody;FTDALS3 antibody;MGC127197 antibody;ORCA antibody;OSF-6 antibody;Osi antibody;OSIL antibody;Oxidative stress induced like antibody;p60 antibody;p62 antibody;p62B antibody;Paget disease of bone 3 antibody;PDB 3 antibody;PDB3 antibody;Phosphotyrosine independent ligand for the Lck SH2 domain of 62 kDa antibody;Phosphotyrosine independent ligand for the Lck SH2 domain p62 antibody;Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa antibody;PKC-zeta-interacting protein antibody;Protein kinase C-zeta-interacting protein antibody;Sequestosome 1 antibody;Sequestosome-1 antibody;SQSTM 1 antibody;SQSTM_HUMAN antibody;Sqstm1 antibody;STAP antibody;STONE14 antibody;Ubiquitin binding protein p62 antibody;Ubiquitin-binding protein p62 antibody;ZIP 3 antibody;ZIP antibody;ZIP3 antibody

SUBCELLULAR LOCATION

Cytoplasm, Endoplasmic reticulum, Endosome, Lysosome, Nucleus.

FUNCTION

Autophagy receptor required for selective macroautophagy (aggrephagy). Functions as a bridge between polyubiquitinated cargo and autophagosomes. Interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Along with WDFY3, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with WDFY3, required to recruit ubiquitinated proteins to PML bodies in the nucleus. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD. May be involved in cell differentiation, apoptosis, immune response and regulation of K+ channels. Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport. Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes. Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes.