Connexin 45 / GJA7 / Cx45 Rabbit Polyclonal Antibody (ER1803-93)

UNIPROT #

P36383

PROTEIN NAME

Connexin 45 / GJA7 / Cx45

SYNONYMS

Connexin 45 / GJA7 antibody;Connexin 45 antibody;Connexin-45 antibody;Connexin45 antibody;CX 31.9 antibody;CX 45 antibody;CX31.9 antibody;Cx45 antibody;CXG1_HUMAN antibody;DKFZp686P0738 antibody;Gap junction alpha 7 protein antibody;Gap junction alpha-7 protein antibody;Gap junction gamma 1 protein antibody;Gap junction gamma-1 protein antibody;Gap junction protein alpha 7 45kDa antibody;Gap junction protein alpha 7 antibody;Gap junction protein, gamma 1, 45kDa antibody;GJA 7 antibody;GJA7 antibody;GJC1 antibody;GJD3 antibody

SEQUENCE SIMILARITIES

Belongs to the connexin family. Gamma-type subfamily.

SUBCELLULAR LOCATION

Cell membrane, Gap junction.

FUNCTION

Gap junction gamma-1 protein (GJC1), also known as gap junction alpha-7 protein (GJA7) and connexin 45 (Cx45) — is a protein that in humans is encoded by the GJC1 gene. Cx45 is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Alternatively spliced transcript variants encoding the same isoform have been described. GJs consist of 3 major connexin (Cx) isoforms—Cx43, Cx40, and Cx45—each of which are characterized by chamber-specific regional distribution and permeation properties. Cx45 is strongly expressed in the early embryonic myocardium and is required for cardiac development (1). Homozygous Cx45-deficient mice are embryonic lethal; however, in the adult heart, Cx45 is expressed mainly at the SA and AV nodes and is not essential for survival of adult mice. Disease-causing mutations in GJ gamma-1 protein (GJC1), which encodes Cx45, have not yet been identified.