Kir3.4 Rabbit Polyclonal Antibody (ER1803-03)

UNIPROT #

P48544

PROTEIN NAME

Kir3.4

SYNONYMS

Cardiac ATP sensitive potassium channel antibody;Cardiac inward rectifier antibody;CIR antibody;G protein activated inward rectifier potassium channel 4 antibody;G protein-activated inward rectifier potassium channel 4 antibody;GIRK 4 antibody;GIRK-4 antibody;GIRK4 antibody;Heart KATP channel antibody;Inward rectifier K(+) channel Kir3.4 antibody;Inward rectifier K+ channel KIR3.4 antibody;Inward rectifier potassium channel KIR3.4 antibody;inwardly rectifying subfamily J member 5 antibody;IRK-4 antibody;IRK5_HUMAN antibody;KATP 1 antibody;KATP-1 antibody;KATP1 antibody;KCNJ 5 antibody;Kcnj5 antibody;KIR 3.4 antibody;KIR3.4 antibody;LQT13 antibody;Potassium channel antibody;Potassium channel inwardly rectifying subfamily J member 5 antibody;Potassium inwardly rectifying channel J5 antibody;Potassium inwardly rectifying channel subfamily J member 5 antibody;potassium voltage-gated channel subfamily J member 5 antibody

SEQUENCE SIMILARITIES

Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ5 subfamily.

TISSUE SPECIFICITY

Islets, exocrine pancreas and heart. Expressed in the adrenal cortex, particularly the zona glomerulosa.

SUBCELLULAR LOCATION

Membrane.

FUNCTION

This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium.