Vinculin Recombinant Rabbit Monoclonal Antibody [JM42-43] (ET1705-94)

UNIPROT #

P18206

PROTEIN NAME

Vinculin

SYNONYMS

CMD1W antibody;CMH15 antibody;Epididymis luminal protein 114 antibody;HEL114 antibody;Metavinculin antibody;MV antibody;MVCL antibody;OTTHUMP00000019861 antibody;OTTHUMP00000019862 antibody;VCL antibody;VINC antibody;VINC_HUMAN antibody;Vinculin antibody

SEQUENCE SIMILARITIES

Belongs to the vinculin/alpha-catenin family.

TISSUE SPECIFICITY

Metavinculin is muscle-specific.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated; on serines, threonines and tyrosines. Phosphorylation on Tyr-1133 in activated platelets affects head-tail interactions and cell spreading but has no effect on actin binding nor on localization to focal adhesion plaques (By similarity).; Acetylated; mainly by myristic acid but also by a small amount of palmitic acid.

SUBCELLULAR LOCATION

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane.

FUNCTION

Focal adhesions are identified as areas within the plasma membrane of tissue culture cells that adhere tightly to the underlying substrate. In vivo, these regions are involved in the adhesion of cells to the extracellular matrix. Paxillin and vinculin are cytoskeletal, focal adhesion proteins that are components of a protein complex which links the Actin network to the plasma membrane. Vinculin binding sites have been identified on other cytoskeletal proteins, including Talin and α-actinin. In addition, vinculin, Talin and α-actinin each contain Actin binding sites. Expression of vinculin and Talin have been shown to be affected by the level of Actin expression. α-Actinin has been shown to link Actin to integrins in the plasma membrane through interactions with the vinculin and Talin complex or by a direct interaction with integrin.