GLO1 Recombinant Rabbit Monoclonal Antibody [JU44-11] (ET7106-68)

UNIPROT #

Q04760

PROTEIN NAME

GLO1

SYNONYMS

Aldoketomutase antibody;glo1 antibody;GLOD1 antibody;Glx I antibody;GLYI antibody;glyoxalase domain containing 1 antibody;Glyoxalase I antibody;Ketone aldehyde mutase antibody;Ketone-aldehyde mutase antibody;Lactoyl glutathione lyase antibody;Lactoylglutathione lyase antibody;LGUL_HUMAN antibody;Methylglyoxalase antibody;S D lactoylglutathione methylglyoxal lyase antibody;S-D-lactoylglutathione methylglyoxal lyase antibody

SEQUENCE SIMILARITIES

Belongs to the glyoxalase I family.

POST-TRANSLATIONAL MODIFICATION

Glutathionylation at Cys-139 inhibits enzyme activity.; Phosphorylated at Thr-107 in the presence of CaMK2. However, this is a consensus site for phosphorylation by CK2 so phosphorylation may be mediated by CK2 rather than CaMK2. Phosphorylation is induced by TNF and suppresses the TNF-induced transcriptional activity of NF-kappa-B.; Exists in a nitric oxide (NO)-modified form. The exact nature of the modification is unknown, but it suppresses the TNF-induced transcriptional activity of NF-kappa-B.

SUBCELLULAR LOCATION

Cytoplasm. Nucleus.

FUNCTION

The glyoxal pathway plays a role in the detoxification of glucose degradation products (GDP). Glyoxalase I (GLO1), a member of the glyoxalase family, is effective in eliminating GDP. Overexpression or silencing of Glyoxalase I in mice brain suggests an association between Glyoxalase I and anxiety. Glyoxalase I has three isoforms generated from two alleles in the genome which forms two homodimers and one heterodimer, each subunit binding one zinc ion. Research demonstrates that GLO1 gene expression is induced in colon carcinoma. Both an insulin response element (IRE), and a zinc metal response element (MRE) in the promoter region of the GLO1 gene have been identified.