MKLP1 Recombinant Rabbit Monoclonal Antibody [SY02-74] (ET1607-63)

UNIPROT #

Q02241

PROTEIN NAME

MKLP1

SYNONYMS

CHO 1 antibody;CHO1 antibody;KIF 23 antibody;KIF23 antibody;KIF23_HUMAN antibody;Kinesin family member 23 antibody;Kinesin like 5 antibody;Kinesin like protein 5 antibody;Kinesin like protein KIF 23 antibody;Kinesin like protein KIF23 antibody;Kinesin-like protein 5 antibody;Kinesin-like protein KIF23 antibody;KNS L5 antibody;KNSL 5 antibody;KNSL5 antibody;Mitotic kinesin like 1 antibody;Mitotic kinesin like protein 1 antibody;Mitotic kinesin-like protein 1 antibody;MKLP 1 antibody

SEQUENCE SIMILARITIES

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

POST-TRANSLATIONAL MODIFICATION

Ubiquitinated. Deubiquitinated by USP8/UBPY.

SUBCELLULAR LOCATION

Cytoplasm, Nucleus, Midbody.

FUNCTION

KIF23 (also known as Kinesin-6, CHO1/MKLP1, C. elegans ZEN-4 and Drosophila Pavarotti) is a member of kinesin-like protein family. This family includes microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein has been shown to cross-bridge antiparallel microtubules and drive microtubule movement in vitro. Alternate splicing of this gene results in two transcript variants encoding two different isoforms, better known as CHO1, the larger isoform and MKLP1, the smaller isoform. KIF23 is a plus-end directed motor protein expressed in mitosis, involved in the formation of the cleavage furrow in late anaphase and in cytokinesis. KIF23 is part of the centralspindlin complex that includes PRC1, Aurora B and 14-3-3 which cluster together at the spindle midzone to enable anaphase in dividing cells. In neuronal development KIF23 is involved in the transport of minus-end distal microtubules into dendrites and is expressed exclusively in cell bodies and dendrites.