PKC alpha Recombinant Rabbit Monoclonal Antibody [SU31-08] (ET1608-15)

UNIPROT #

P17252

PROTEIN NAME

PKC alpha

SYNONYMS

AAG6 antibody;Aging associated gene 6 antibody;aPKC antibody;KPCA_HUMAN antibody;PKC alpha antibody;PKC-A antibody;PKC-alpha antibody;PKCA antibody;PRKACA antibody;PRKCA antibody;Protein Kinase C alpha antibody;Protein kinase C alpha type antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.

SUBCELLULAR LOCATION

Cytoplasm, Nucleus, Cell membrane, Mitochondrion membrane.

FUNCTION

Protein kinase C alpha (PKCα) is an enzyme that in humans is encoded by the PRKCA gene. Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca2+ handling in myocytes. Protein kinase C-alpha (PKC-α) is a specific member of the protein kinase family. These enzymes are characterized by their ability to add a phosphate group to other proteins, thus changing their function.