CD73 Recombinant Rabbit Monoclonal Antibody [PSH09-57] (HA723119)

UNIPROT #

P21589

PROTEIN NAME

CD73

SYNONYMS

5' NT antibody;5' nucleotidase (CD73) antibody;5' nucleotidase precursor antibody;5' nucleotidase, ecto antibody;5' nucleotidase, ecto (CD73) antibody;5'-NT antibody;5'-nucleotidase antibody;5NTD_HUMAN antibody;CD73 antibody;CD73 antigen antibody;E5NT antibody;Ecto 5' nucleotidase antibody;Ecto-5'-nucleotidase antibody;eN antibody;eNT antibody;NT antibody;NT5 antibody;NT5E antibody;NTE antibody;Purine 5 Prime Nucleotidase antibody

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

5′-nucleotidase (5′-NT), also known as ecto-5′-nucleotidase or CD73 (cluster of differentiation 73), is an enzyme that in humans is encoded by the NT5E gene. CD73 commonly serves to convert AMP to adenosine. Ecto-5-prime-nucleotidase (5-prime-ribonucleotide phosphohydrolase; EC 3.1.3.5) catalyzes the conversion at neutral pH of purine 5-prime mononucleotides to nucleosides, the preferred substrate being AMP. The enzyme consists of a dimer of 2 identical 70-kD subunits bound by a glycosyl phosphatidyl inositol linkage to the external face of the plasma membrane. The enzyme is used as a marker of lymphocyte differentiation. Consequently, a deficiency of NT5 occurs in a variety of immunodeficiency diseases. Other forms of 5-prime nucleotidase exist in the cytoplasm and lysosomes and can be distinguished from ecto-NT5 by their substrate affinities, requirement for divalent magnesium ion, activation by ATP, and inhibition by inorganic phosphate. Rare allelic variants are associated with a syndrome of adult-onset calcification of joints and arteries (CALJA) affecting the iliac, femoral, and tibial arteries reducing circulation in the legs and the joints of the hands and feet causing pain.