DDIT4 Recombinant Rabbit Monoclonal Antibody [PS00-10] (HA722161)

UNIPROT #

Q9NX09

PROTEIN NAME

DDIT4

SYNONYMS

DDIT4 antibody;DDIT4_HUMAN antibody;Dig2 antibody;DNA damage inducible transcript 4 antibody;DNA damage inducible transcript 4 protein antibody;DNA damage-inducible transcript 4 protein antibody;FLJ20500 antibody;HIF 1 responsive protein RTP801 antibody;HIF 1 responsive RTP801 antibody;HIF-1 responsive protein RTP801 antibody;Protein regulated in development and DNA damage response 1 antibody;REDD-1 antibody;REDD1 antibody;RTP801 antibody

SUBCELLULAR LOCATION

Mitochondrion, Cytoplasm, cytosol.

FUNCTION

Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes (By similarity). Required for mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity). Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal neuron migration during embryonic brain development. Plays a role in neuronal cell death.