IREB2 Rabbit Polyclonal Antibody (R1706-12)

UNIPROT #

P48200

PROTEIN NAME

IREB2

SYNONYMS

ACO3 antibody;FLJ23381 antibody;IRE BP2 antibody;IRE-BP 2 antibody;IREB 2 antibody;IREB2 antibody;IREB2_HUMAN antibody;Iron regulatory protein 2 antibody;iron responsive element binding protein 2 antibody;Iron-responsive element-binding protein 2 antibody;IRP 2 antibody;IRP2 antibody;IRP2AD antibody;OTTHUMP00000185022 antibody

SEQUENCE SIMILARITIES

Belongs to the aconitase/IPM isomerase family.

POST-TRANSLATIONAL MODIFICATION

Ubiquitinated and degraded by the proteasome in presence of high level of iron and oxygen. Ubiquitinated by a SCF complex containing FBXL5. Upon iron and oxygen depletion FBXL5 is degraded, preventing ubiquitination and allowing its RNA-binding activity.

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

Iron metabolism is essential for sustaining mammalian homeostasis. Iron uptake and distribution is a highly regulated process in mammalian cells that is monitored by two iron sensing proteins: IRP-1 and -2 (iron regulatory protein-1 and -2), also known as iron responsive element-binding protein-1 and -2 (IRE-BP-1 and -2) or aconitase 1 and 2. IRP-1 and IRP-2 are important soluble regulatory factors that mediate iron uptake and storage in mammalian cells. They are capable of either repressing translation or enhancing mRNA stability by associating with stem-loop motifs known as iron-responsive elements (IREs). IRPs respond to stress mediators, iron concentration and signaling factors, including nitrogen monoxide, cytokines and hydrogen peroxide.