KCNA5 / KV1-5 Recombinant Rabbit Monoclonal Antibody [PSH12-30] (HA723455)

UNIPROT #

P22460

PROTEIN NAME

KCNA5 / KV1-5

SYNONYMS

ATFB7 antibody;cardiac potassium channel antibody;HCK1 antibody;HK2 antibody;HPCN1 antibody;insulinoma and islet potassium channel antibody;KCNA5 antibody;KCNA5_HUMAN antibody;KV1.5 antibody;PCN1 antibody;potassium channel 1 antibody;Potassium channel, insulinoma and islet cell antibody;Potassium channel, voltage-gated, shaker-related subfamily, member 5 antibody;Potassium voltage gated channel subfamily A member 5 antibody;Potassium voltage-gated channel subfamily A member 5 antibody;Voltage-gated potassium channel HK2 antibody;voltage-gated potassium channel protein Kv1.5 antibody;Voltage-gated potassium channel subunit Kv1.5 antibody

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

KCNA5 is a voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. It forms tetrameric, potassium-selective channels, allowing potassium ions to pass according to their electrochemical gradient. The channel alternates between open and closed states in response to changes in membrane voltage, contributing to the regulation of electrical activity in cells. KCNA5 can form functional homotetrameric channels or heterotetrameric channels with other KCNA family members, such as KCNA1, KCNA2, KCNA4, and KCNA5, which influence channel properties. This channel is critical for normal electrical conduction, including the formation of the ventricular conduction system and action potential configuration. It may also play a role in regulating insulin secretion in pancreatic islets. KCNA5 is associated with delayed rectifier potassium currents, which help restore the resting membrane potential after depolarization, particularly in beta cells. Defects in KCNA5 are linked to familial atrial fibrillation (ATFB7), a condition characterized by irregular heart rhythms that can lead to stroke or heart failure. Additionally, KCNA5 is implicated in pulmonary vascular function, where it helps set the resting membrane potential and participates in hypoxic pulmonary vasoconstriction.