PLC-gamma-1 Recombinant Rabbit Monoclonal Antibody [SN06-10] (ET1611-25)

UNIPROT #

P19174

PROTEIN NAME

Phospholipase C gamma 1

SYNONYMS

1 phosphatidyl D myo inositol 4 5 bisphosphate antibody;1 phosphatidylinositol 4 5 bisphosphate phosphodiesterase gamma 1 antibody;1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 antibody;Inositoltrisphosphohydrolase antibody;Monophosphatidylinositol phosphodiesterase antibody;NCKAP3 antibody;Phosphatidylinositol phospholipase C antibody;Phosphoinositidase C antibody;Phosphoinositide phospholipase C antibody;Phosphoinositide phospholipase C-gamma-1 antibody;Phospholipase C 148 antibody;Phospholipase C gamma 1 antibody;Phospholipase C-gamma-1 antibody;Phospholipase C-II antibody;PLC gamma 1 antibody;PLC II antibody;PLC-148 antibody;PLC-gamma-1 antibody;PLC-II antibody;PLC1 antibody;PLC148 antibody;Plcg1 antibody;PLCG1_HUMAN antibody;PLCgamma1 antibody

POST-TRANSLATIONAL MODIFICATION

Tyrosine phosphorylated in response to signaling via activated FLT3, KIT and PDGFRA (By similarity). Tyrosine phosphorylated by activated FGFR1, FGFR2, FGFR3 and FGFR4. Tyrosine phosphorylated by activated FLT1 and KDR. Tyrosine phosphorylated by activated PDGFRB. The receptor-mediated activation of PLCG1 involves its phosphorylation by tyrosine kinases, in response to ligation of a variety of growth factor receptors and immune system receptors. For instance, SYK phosphorylates and activates PLCG1 in response to ligation of the B-cell receptor. May be dephosphorylated by PTPRJ. Phosphorylated by ITK and TXK on Tyr-783 upon TCR activation in T-cells.; Ubiquitinated by CBLB in activated T-cells.

SUBCELLULAR LOCATION

Cell projection.

FUNCTION

Phospholipase C, gamma 1, also known as PLCG1,is a protein that in humans involved in cell growth, migration, apoptosis, and proliferation. It is encoded by the PLCG1 gene and is part of the PLC superfamily. PLCγ1 is used during the cell growth and in a cell migration and apoptosis, all of which are vital cell processes that, if disrupted by mutations, can cause cancerous cells to form within the body. Mutations in this protein show an increase in issues in cells regarding regulation of proliferation and their cell signaling. PLCγ1 roles are also involved in neuronal actin growth, calcium signaling, and brain development. It is highly regulated by multiple factors, such as PIK3, AMPK, and FAK. It is part of the PIP3 pathway and leads to and increase in calcium in the cells. In neuronal cells, PLCγ1 is highly involved in actin cytoskeleton organization and synaptic plasticity.