ABCA1 Rabbit Polyclonal Antibody (R1510-42)

UNIPROT #

O95477

PROTEIN NAME

ABCA1

SYNONYMS

ABC 1 antibody;ABC Transporter 1 antibody;ABC-1 antibody;ABC1 antibody;ABCA 1 antibody;ABCA1 antibody;ABCA1_HUMAN antibody;ATP binding Cassette 1 antibody;ATP binding cassette sub family A ABC1 member 1 antibody;ATP binding cassette sub family A member 1 antibody;ATP binding Cassette Transporter 1 antibody;ATP-binding cassette 1 antibody;ATP-binding cassette sub-family A member 1 antibody;ATP-binding cassette transporter 1 antibody;CERP antibody;Cholesterol efflux regulatory protein antibody;FLJ14958 antibody;HDLDT1 antibody;Membrane bound antibody;MGC164864 antibody;MGC165011 antibody;TD antibody;TGD antibody

SEQUENCE SIMILARITIES

Belongs to the ABC transporter superfamily. ABCA family.

TISSUE SPECIFICITY

Widely expressed, but most abundant in macrophages.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation on Ser-2054 regulates phospholipid efflux.; Palmitoylation by DHHC8 is essential for membrane localization.

SUBCELLULAR LOCATION

Membrane

FUNCTION

ABC1 (for ATP-binding cassette transporter 1) is a member of the family of ATP-binding cassette proteins which transport various molecules across biological membranes. ABC1 contains two characteristic ATP-binding domains and 12 transmembrane domains which form a channel-like structure for transport. Mutations in the ABC1 gene are implicated in Tangier disease, characterized by low serum high density lipoprotein. ABC1 is widely expressed in human tissues, with high levels of expression in liver, lung, adrenal glands, placenta and fetal tissue. ABC1 expression is induced during monocyte differentiation and upregulated in the presence of acetylated low-density lipoprotein. ABC1 may have a dual regulatory function in macrophage lipid metabolism and inflammation.