Apolipoprotein A II Recombinant Rabbit Monoclonal Antibody [JB70-35] (ET7107-47)

UNIPROT #

P02652

PROTEIN NAME

Apolipoprotein A II

SYNONYMS

APO A2 antibody;Apo AII antibody;Apo-AII antibody;APOA 2 antibody;ApoA II antibody;ApoA-II antibody;APOA2 antibody;APOA2_HUMAN antibody;APOAII antibody;Apolipoprotein A II antibody;Apolipoprotein A-II(1-76) antibody;Apolipoprotein A2 antibody;Apolipoprotein AII antibody;ApolipoproteinA II antibody;OTTHUMP00000032244 antibody

SEQUENCE SIMILARITIES

Belongs to the apolipoprotein A2 family.

TISSUE SPECIFICITY

Plasma; synthesized in the liver and intestine.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation sites are present in the extracellular medium.; Apolipoprotein A-II is O-glycosylated.

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Apolipoproteins are protein components of plasma lipoproteins. The human apoA-I gene encodes a single chain, 243 amino acid protein which promotes cholesterol efflux from tissues to the liver for excretion. Apolipoprotein A-I is the major protein component of high density lipoprotein (HDL) in the plasma. It can function as a co-factor for lecithin cholesterolacyltransferase (LCAT), which is responsible for the formation of most plasma cholesterylesters. The human apoA-II gene encodes the second most abundant protein of HDL particles, where it influences plasma levels of free fatty acids (FFA). The human apoA-IV gene encodes a 396 amino acid preprotein, which after proteolytic processing is secreted from the intestine in association with chylomicron particles. ApoA-IV is a potent activator of LCAT in vitro. The human apoA-V gene encodes a 366 amino acid protein that is believed to be an important determinant of plasma triglyceride levels.