HMGCR Recombinant Rabbit Monoclonal Antibody [JF0981] (ET1702-41)

UNIPROT #

P04035

PROTEIN NAME

HMGCR

SYNONYMS

3 hydroxy 3 methylglutaryl CoA reductase antibody;3 hydroxy 3 methylglutaryl Coenzyme A reductase antibody;3 hydroxymethylglutaryl CoA reductase antibody;3-hydroxy-3-methylglutaryl CoA reductase (NADPH) antibody;3-hydroxy-3-methylglutaryl-coenzyme A reductase antibody;3H3M antibody;HMDH_HUMAN antibody;HMG CoA reductase antibody;HMG CoAR antibody;HMG-CoA reductase antibody;Hmgcr antibody;Hydroxymethylglutaryl CoA reductase antibody;LDLCQ3 antibody;MGC103269 antibody;Red antibody

SEQUENCE SIMILARITIES

Belongs to the HMG-CoA reductase family.

POST-TRANSLATIONAL MODIFICATION

N-glycosylated. Deglycosylated by NGLY1 on release from the endoplasmic reticulum (ER) in a sterol-mediated manner.; Undergoes sterol-mediated ubiquitination and ER-associated degradation (ERAD). Accumulation of sterols in the endoplasmic reticulum (ER) membrane, triggers binding of the reductase to the ER membrane protein INSIG1. This INSIG1 binding leads to the recruitment of the ubiquitin ligase, AMFR/gp78 or RNF145, initiating ubiquitination of the reductase. The ubiquitinated reductase is then extracted from the ER membrane and delivered to cytosolic 26S proteosomes by a mechanism probably mediated by the ATPase Valosin-containing protein VCP/p97. Lys-248 is the main site of ubiquitination. Ubiquitination is enhanced by the presence of a geranylgeranylated protein.

SUBCELLULAR LOCATION

Endoplasmic reticulum membrane.

FUNCTION

The human enzyme hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) limits the rate of cholesterol synthesis, a necessary process for cellular growth, in liver tissue. Phosphorylation of HMGCR inactivates the enzyme, which occurs via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from the product of the reductase reaction. Inhibitors of HMGCR (statins) exert anti-inflammatory effects and decrease the frequency of cardiovascular events by lowering plasma cholesterol. Additionally, intermediate products along the pathway catalyzed by HMGCR, which modulate signal transducing proteins such as Ras, provide possible ties between HMGCR regulation and new chemotherapeutic methods.