Fibulin 5 Mouse Monoclonal Antibody [A1C12] (HA600044)

UNIPROT #

Q9UBX5

PROTEIN NAME

Fibulin 5

SYNONYMS

ADCL2 antibody;ARCL1A antibody;ARMD3 antibody;Dance antibody;Developmental arteries and neural crest EGF like protein antibody;Developmental arteries and neural crest EGF-like protein antibody;EVEC antibody;Fbln5 antibody;FBLN5_HUMAN antibody;FIBL 5 antibody;FIBL-5 antibody;Fibulin-5 antibody;FLJ90059 antibody;UP50 antibody;Urine p50 protein antibody

SUBCELLULAR LOCATION

Secreted, extracellular matrix.

FUNCTION

Fibulin-5 (also known as DANCE (developmental arteries and neural crest epidermal growth factor (EGF)-like)) is a protein that in humans is encoded by the FBLN5 gene. The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. FBLN5 has been shown to interact with LOXL1 and apolipoprotein(a). FBLN5 mutations have been described in patients with age-related macular degeneration, as well as being involved in Charcot-Marie-Tooth neuropathies.