PDCD6 Mouse Monoclonal Antibody [A6A7] (HA600092)

UNIPROT #

O75340

PROTEIN NAME

PDCD6

SYNONYMS

AIP1 antibody;ALG 2 antibody;ALG-2-interacting protein 1 antibody;ALG2 antibody;ALIX antibody;Apoptosis linked gene 2 antibody;Apoptosis linked gene 2 protein antibody;Apoptosis-linked gene 2 protein antibody;FLJ42309 antibody;FLJ46208 antibody;Hp95 antibody;KIAA1375 antibody;MA 3 antibody;MA3 antibody;MGC111017 antibody;MGC119050 antibody;MGC9123 antibody;PDCD 6 antibody;Pdcd6 antibody;PDCD6_HUMAN antibody;PEF 1B antibody;PEF1B antibody;Probable calcium binding protein ALG 2 antibody;Probable calcium binding protein ALG2 antibody;Probable calcium-binding protein ALG-2 antibody;Programmed cell death 6 antibody;Programmed cell death 6-interacting protein antibody;Programmed cell death protein 6 antibody;PS 2 antibody;PS2 antibody

SUBCELLULAR LOCATION

Endosome, Nucleus, Endoplasmic reticulum membrane, Cytoplasm, COPII-coated vesicle membrane.

FUNCTION

Programmed cell death protein 6 is a protein that in humans is encoded by the PDCD6 gene. This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, apoptosis was not blocked suggesting this gene product is functionally redundant. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is also located on the short arm of chromosome 5.