TRADD Rabbit Polyclonal Antibody (ER1901-79)

UNIPROT #

Q15628

PROTEIN NAME

TRADD

SYNONYMS

9130005N23Rik antibody;AA930854 antibody;TNFR1 associated DEATH domain protein antibody;TNFR1-associated DEATH domain protein antibody;TNFRSF1A associated via death domain antibody;TNFRSF1A-associated via death domain antibody;tradd antibody;TRADD_HUMAN antibody;Tumor necrosis factor receptor type 1 associated DEATH domain protein antibody;Tumor necrosis factor receptor type 1-associated DEATH domain protein antibody

TISSUE SPECIFICITY

Found in all examined tissues.

SUBCELLULAR LOCATION

Cytoplasm. Cytoskeleton. Nucleus.

FUNCTION

Tumor necrosis factor receptor type 1-associated DEATH domain protein is a protein that in humans is encoded by the TRADD gene. The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.