Bid Recombinant Rabbit Monoclonal Antibody [JM11-14] (ET1703-92)

UNIPROT #

P55957

PROTEIN NAME

Bid

SYNONYMS

Apoptic death agonist antibody;Apoptotic death agonist BID antibody;BH3 interacting domain death agonist antibody;BH3 interacting domain death agonist p11 antibody;BH3 interacting domain death agonist p13 antibody;BH3 interacting domain death agonist p15 antibody;BH3-interacting domain death agonist p11 antibody;BID antibody;BID isoform ES(1b) antibody;BID isoform L(2) antibody;BID isoform Si6 antibody;BID_HUMAN antibody;Desmocollin type 4 antibody;FP497 antibody;Human BID coding sequence antibody;MGC15319 antibody;MGC42355 antibody;p11 BID antibody;p13 BID antibody;p15 BID antibody;p22 BID antibody

TISSUE SPECIFICITY

Isoform 2 and isoform 3 are expressed in spleen, bone marrow, cerebral and cerebellar cortex. Isoform 2 is expressed in spleen, pancreas and placenta (at protein level). Isoform 3 is expressed in lung, pancreas and spleen (at protein level). Isoform 4 is expressed in lung and pancreas (at protein level).

POST-TRANSLATIONAL MODIFICATION

TNF-alpha induces a caspase-mediated cleavage of p22 BID into a major p15 and minor p13 and p11 products.; p15 BID is ubiquitinated by ITCH; ubiquitination results in proteasome-dependent degradation.

SUBCELLULAR LOCATION

Cytoplasm. Mitochondrion membrane.

FUNCTION

Members of the Bcl-2 family of proteins interact to regulate programmed cell death, or apoptosis. Various homodimers and heterodimers formed by proteins in this family can either promote or inhibit apoptosis. Bcl-2 blocks cell death following a variety of stimuli and confers a death-sparing effect on certain hematopoietic cell lines following growth factor withdrawal. Additional apoptotic inhibitors in this family include A1, Bag-1, Bcl-w, Bcl-x and Mcl-1. Pro-apoptotic members of this family include Bax, Bad, Bak, Bik (NBK) and BID. BID contains a BH3 domain which allows it to dimerize with and counter the death repressor effects of Bcl-2. BID has also been shown to heterodimerize with Bcl-x and the death agonist Bax. BID is localized predominantly in the cytosol and is also present in membrane fractions. It is highly expressed in kidney and can also be detected in brain, spleen, liver, testis and lung.