Prohibitin Recombinant Rabbit Monoclonal Antibody [SR46-02] (ET1602-31)

UNIPROT #

P35232

PROTEIN NAME

Prohibitin

SYNONYMS

Epididymis luminal protein 215 antibody;Epididymis secretory sperm binding protein Li 54e antibody;HEL 215 antibody;HEL S 54e antibody;PHB antibody;PHB_HUMAN antibody;PHB1 antibody;Prohibitin antibody

SEQUENCE SIMILARITIES

Belongs to the prohibitin family.

TISSUE SPECIFICITY

Widely expressed in different tissues.

DEVELOPMENTAL STAGE

Levels of expression in fibroblasts decrease heterogeneously during cellular aging.

SUBCELLULAR LOCATION

Cell membrane, Cytoplasm, Membrane, Mitochondrion, Mitochondrion inner membrane, Nucleus.

FUNCTION

Prohibitin is an evolutionarily conserved protein that has antiproliferative activity. The gene encoding human prohibitin maps to chromosome 17q21 and is ubiquitously expressed. Prohibitin is a post-synthetically modified protein that is localized in the inner membrane of mitochondria, where it regulates the cell cycle by blocking the transition between the G1 and S phases, and on the plasma membrane of B cells, where it mediates B cell maturation. Prohibitin mRNA and protein levels are high in G1, decline during the S phase, rise again in G2 and decline in M phase, which suggests that prohibitin controls the cell cycle by using both transcriptional and posttranslational mechanisms. Prohibitin is also a potential tumor suppressor protein that binds to retinoblastoma (Rb) and subsequently inhibits the activity of E2F family members in response to specific signaling cascades. Prohibitin 2 is a repressor of estrogen receptor activity, and is required for somatic and germline differentiation in the larval gonad during embryonic development. Mutations in the Prohibitin genes are correlated with breast cancer development and/or progressionin more than 80% of the cell lines analyzed.