BAT3 Recombinant Rabbit Monoclonal Antibody [JE54-90] (ET7110-88)

UNIPROT #

P46379

PROTEIN NAME

BAT3

SYNONYMS

2410045D21Rik antibody;AA408914 antibody;BAG 6 antibody;BAG family molecular chaperone regulator 6 antibody;BAG-6 antibody;BAG6 antibody;BAG6_HUMAN antibody;BAT 3 antibody;BAT3 antibody;BCL2-associated athanogene 6 antibody;D17H6S52E antibody;D6S52E antibody;G3 antibody;HLA B associated transcript 3 antibody;HLA-B associated transcript 3 antibody;HLA-B associated transcript-3 antibody;HLA-B-associated transcript 3 antibody;large proline rich protein BAG6 antibody;Large proline rich protein BAT3 antibody;Large proline-rich protein BAG6 antibody;large proline-rich protein BAT3 antibody;Protein G3 antibody;Protein Scythe antibody;Scythe antibody;Scythe, homolog of Xenopus antibody

TISSUE SPECIFICITY

Expressed by immature dendritic cells (at protein level).

POST-TRANSLATIONAL MODIFICATION

Ricin can induce a cleavage by the caspase CASP3. The released C-terminal peptide induces apoptosis.; (Microbial infection) In case of infection by L.pneumophila, ubiquitinated by the SCF(LegU1) complex.

SUBCELLULAR LOCATION

Extracellular exosome, cytosol, nucleus.

FUNCTION

ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins. Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum. Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated by RNF126, an E3 ubiquitin-protein ligase associated with BAG6 and are sorted to the proteasome. SGTA which prevents the recruitment of RNF126 to BAG6 may negatively regulate the ubiquitination and the proteasomal degradation of client proteins.