Cullin-3 Rabbit Polyclonal Antibody (ER1706-70)

UNIPROT #

Q13618

PROTEIN NAME

Cullin-3

SYNONYMS

CUL 3 antibody;Cul-3 antibody;cul3 antibody;CUL3_HUMAN antibody;Cullin-3 antibody;Cullin3 antibody;KIAA0617 antibody;PHA2E antibody

SEQUENCE SIMILARITIES

Belongs to the cullin family.

TISSUE SPECIFICITY

Brain, spermatozoa, and testis (at protein level). Widely expressed.

POST-TRANSLATIONAL MODIFICATION

Neddylated. Attachment of NEDD8 is required for the E3 ubiquitin-protein ligase activity of the BCR complex. Deneddylated via its interaction with the COP9 signalosome (CSN) complex.

SUBCELLULAR LOCATION

Golgi apparatus. Nucleus.

FUNCTION

Cullin 3 is a protein that in humans is encoded by the CUL3 gene. Cullin 3 protein belongs to the family of cullins which in mammals contains eight proteins (Cullin 1, Cullin 2, Cullin 3, Cullin 4A, Cullin 4B, Cullin 5, Cullin 7 and Cullin 9). Cullin proteins are an evolutionarily conserved family of proteins throughout yeast, plants and mammals. Cullin 3 is a component of Cullin-RING E3 ubiquitin ligases complexes (CRLs) which are involved in protein ubiquitylation and represent a part of ubiquitin–proteasome system (UPS). Added ubiquitin moieties to the lysine residue by CRLs then target the protein for the proteasomal degradation. Cullin-RING E3 ubiquitin ligases are involved in many cellular processes responsible for cell cycle regulation, stress response, protein trafficking, signal transduction, DNA replication, transcription, protein quality control, circadian clock and development. Deletion of CUL3 gene in mice causes embryonic lethality.