ELMO1 Recombinant Rabbit Monoclonal Antibody [JG34-59] (ET7108-06)

UNIPROT #

Q92556

PROTEIN NAME

ELMO1

SYNONYMS

CED 12 antibody;Ced 12 homolog 1 antibody;Ced 12 homolog antibody;CED-12 antibody;CED12 antibody;Ced12 homolog 1 antibody;Ced12 homolog antibody;ELMO 1 antibody;ELMO-1 antibody;Elmo1 antibody;ELMO1_HUMAN antibody;Engulfment and cell motility 1 antibody;Engulfment and cell motility protein 1 antibody;KIAA0281 antibody;MGC126406 antibody;Protein ced-12 homolog antibody

TISSUE SPECIFICITY

Widely expressed, with a higher expression in the spleen and placenta.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated by HCK.

SUBCELLULAR LOCATION

Cell membrane, Cytoplasm, Membrane.

FUNCTION

Elmo (engulfment and cell motility) proteins share similarity to C. elegans CED-12. The C. elegans genes ced-2, ced-5, ced-10 and ced-12, and their mammalian homologs, CRKII, DOCK1, RAC1 and ELMO, mediate cytoskeletal rear-rangements during phagocytosis of apoptotic cells as well as cell motility. Elmo1 associates with DOCK 180 and may influence phagocytosis and effect cell shape changes. Src family kinase-mediated tyrosine phosphorylation of Elmo1 influences signaling through Elmo1/Crk/DOCK 180 pathways. Elmo2 interacts directly with Rho G in a GTP-dependent manner and forms a ternary complex with DOCK 180 to induce activation of Rac 1. The Rho G-Elmo2-DOCK 180 pathway is required for activation of Rac 1 and cell spreading mediated by integrin, as well as for neurite outgrowth induced by nerve growth factor. Elmo3 acts in assocation with DOCK 180 and Crk II and may be required in complex with DOCK 180 to activate Rac/Rho small GTPases.