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IL-1 beta Recombinant Rabbit Monoclonal Antibody [JJ087-3] (ET1701-39)

Price: Regular price $385.00

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Catalog# ET1701-39

Rabbit Monoclonal to IL-1 beta

Tested for

  • WB

  • IF-Cell

  • IF-Tissue

  • IHC-P

  • FC

Reacts with

  • Human

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free
This product has been cited in peer reviewed publications, see list HERE

Safety datasheet

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Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

IL-1 beta Recombinant Rabbit Monoclonal Antibody [JJ087-3] (ET1701-39)

Immunogen

Synthetic peptide within c-terminal human il1 beta.

Host

Rabbit

Positive Control

THP-1 treated with 80nM TPA overnight then treated with 100ng/mL LPS for 6 hours and 300ng/mL BFA for 3 hours whole cell lysate, A431, Hela, human kidney tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

JJ087-3

RRID

AB_3070207

APPLICATION DILUTION

  • WB

  • 1:1,000

  • IF-Cell

  • 1:50-1:200

  • IF-Tissue

  • 1:50-1:200

  • IHC-P

  • 1:50-1:200

  • FC

  • 1:50-1:100

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 31 kDa

Isotype

IgG

TARGET

UNIPROT #

P01584

PROTEIN NAME

IL-1 beta

SYNONYMS

Catabolin antibody;H1 antibody;IL 1 antibody;IL 1 beta antibody;IL-1 beta antibody;IL1 BETA antibody;IL1B antibody;IL1B_HUMAN antibody;IL1F2 antibody;Interleukin 1 beta antibody;Interleukin-1 beta antibody;OAF antibody;OTTHUMP00000162031 antibody;Preinterleukin 1 beta antibody;Pro interleukin 1 beta antibody

SEQUENCE SIMILARITIES

Belongs to the IL-1 family.

TISSUE SPECIFICITY

Expressed in activated monocytes/macrophages (at protein level).

POST-TRANSLATIONAL MODIFICATION

Activation of the IL1B precursor involves a CASP1-catalyzed proteolytic cleavage. Processing and secretion are temporarily associated.

SUBCELLULAR LOCATION

Cytoplasm, Lysosome, extracellular exosome, Secreted.

FUNCTION

Two forms of interleukin-1, designated IL-1α and IL-1β, have been described. Although encoded by distinct genes and exhibiting roughly only 25% sequence identity, IL-1α and IL-1β bind to the same receptor and seem to elicit similar biological responses. IL-1 production is generally thought to be associated with inflammation, but it has also been shown to be expressed during kidney development, thymocyte differentiation and cartilage degradation. IL-1 plays a critical role in the regulation of immune response and inflammation, acting as an activator of T and B lymphocytes and natural killer (NK) cells. In T cells, IL-1 stimulates the production of IL-2 and selectively inhibits IL-4 expression. IL-1 induces B cell proliferation and maturation, and immunoglobulin synthesis. NK cells require IL-1β for production of the anti- pathogen IFN-γ. IL-1 has also been implicated in several pathological conditions including rheumatoid arthritis, inflammatory bowel disease and atherosclerosis.

CITATIONS

  • Song S, Wang Q, Qu Y, et al

    Pregabalin inhibits purinergic P2Y2 receptor and TRPV4 to suppress astrocyte activation and to relieve neuropathic pain

  • Lei, B., Liu, J., Yao, Z., Xiao, Y., Zhang, X., Zhang, Y., & Xu, J.

    NF-κB-Induced Upregulation of miR-146a-5p Promoted Hippocampal Neuronal Oxidative Stress and Pyroptosis via TIGAR in a Model of Alzheimer's Disease. Frontiers in cellular neuroscience, 15, 653881.

  • Dong Wenyu,et al

    MICT ameliorates hypertensive nephropathy by inhibiting TLR4/NF-κB pathway and down-regulating NLRC4 inflammasome

  • Huang Xiuhong,et al

    Polyphenol-Based Photothermal Nanoparticles with Sprayable Capability for Self-regulation of Microenvironment to Accelerate Diabetic Wound Healing

  • Feng Zhuan,et al

    Inhibition of Ferroptosis Rescues M2 Macrophages and Alleviates Arthritis by Suppressing the HMGB1/TLR4/STAT3 Axis in M1 Macrophages

  • Li, Xin;Wang, Chunchun;Zhu, Jiang;Lin, Qian;Yu, Minjie;Wen, Jiashu;Feng, Jie;Hu, Caihong

    Sodium Butyrate Ameliorates Oxidative Stress-Induced Intestinal Epithelium Barrier Injury and Mitochondrial Damage through AMPK-Mitophagy Pathway

  • Lai Weizhi,et al

    DIREN mitigates DSS-induced colitis in mice and attenuates collagen deposition via inhibiting the Wnt/β-catenin and focal adhesion pathways

  • VEGF-Modified PVA/Silicone Nanofibers Enhance Islet Function Transplanted in Subcutaneous Site Followed by Device-Less Procedure

  • Mi Ai,et al

    Hepatoprotective efficacy and interventional mechanism of panaxanediol saponins component in high-fat diet-induced NAFLD mice

  • Curcumin attenuates MSU crystal-induced inflammation by inhibiting the degradation of IκBα and blocking mitochondrial damage.

  • Huang Xiuhong,Fu Meimei,Lu Min,et al

    Polyphenol-Based Photothermal Nanoparticles with Sprayable Capability for Self-regulation of Microenvironment to Accelerate Diabetic Wound Healing

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