Mad2L2 Recombinant Rabbit Monoclonal Antibody [JU99-23] (ET1706-38)

UNIPROT #

Q9UI95

PROTEIN NAME

Mad2L2

SYNONYMS

Homolog of REV7 S cerevisiae antibody;hREV7 antibody;MAD2 (mitotic arrest deficient yeast, homolog) like 2 antibody;MAD2 homolog antibody;MAD2 like 2 antibody;MAD2 mitotic arrest deficient like 2 antibody;MAD2-like protein 2 antibody;MAD2B antibody;Mad2l2 antibody;MD2L2_HUMAN antibody;Mitotic Arrest Deficient 2 L2 antibody;Mitotic arrest deficient 2-like protein 2 antibody;Mitotic arrest deficient homolog like 2 antibody;Mitotic arrest deficient like 2 (yeast) antibody;Mitotic arrest deficient yeast homolog antibody;Mitotic spindle assembly checkpoint protein MAD2B antibody;Polymerase (DNA directed) zeta 2 accessory subunit antibody;POLZ2 antibody;REV 7 antibody;REV7 antibody;REV7 homolog antibody;Weakly similar to Mitotic MAD2 protein (S cerevisiae) antibody

TISSUE SPECIFICITY

Ubiquitously expressed.

SUBCELLULAR LOCATION

Nucleus. Cytoplasm.

FUNCTION

Cell cycle progression is subject to arrest at the mitotic spindle assembly checkpoint in response to incorrect spindle fiber assembly. MAD2 (for mitotic arrest-deficient) is a component of the mitotic spindle checkpoint. Cells with mutated MAD2 do not undergo mitotic arrest in response to incorrect spindle fiber assembly, which results in missegregation and eventual cell death. A breast carcinoma cell line with reduced MAD2 expression, T-47D, was shown to complete mitosis in the presence of Nocodazole, an inhibitor of mitotic spindle assembly. MAD2 is localized to unattached kinetochores during pro-metaphase and disassociates upon spindle fiber attachment, indicating that MAD2 regulates kinetochore binding to the spindle fibers. Human MAD2 has also been shown to associate with Insulin receptor (IR), but not IGF-IR, implicating MAD2 as a mediator for IR-specific signaling. MAD2B, a MAD2 homolog, is required for the execution of the mitotic checkpoint monitoring the kinetochore-spindle attachment process and, if the process is not complete, MAD2B delays the onset of anaphase.