ROCK1 Recombinant Rabbit Monoclonal Antibody [ST05-19] (ET1609-53)

UNIPROT #

Q13464

PROTEIN NAME

ROCK1

SYNONYMS

coiled-coil-containing protein kinase 1 antibody;coiled-coil-containing protein kinase I antibody;MGC131603 antibody;MGC43611 antibody;p160 Rhoassociated coiled coil-forming protein kinase antibody;p160 ROCK-1 antibody;p160 ROCK1 antibody;p160ROCK antibody;PRO0435 antibody;Renal carcinoma antigen NY REN 35 antibody;Renal carcinoma antigen NY-REN-35 antibody;Rho associated coiled coil containing protein kinase 1 antibody;Rho associated protein kinase 1 antibody;Rho kinase antibody;Rho-alpha kinase antibody;Rho-associated antibody;Rho-associated protein kinase 1 antibody;ROCK I antibody;ROCK-I antibody;ROCK1 antibody;ROCK1_HUMAN antibody;Rok antibody;rokalpha antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

TISSUE SPECIFICITY

Detected in blood platelets.

POST-TRANSLATIONAL MODIFICATION

Autophosphorylated on serine and threonine residues.; Cleaved by caspase-3 during apoptosis. This leads to constitutive activation of the kinase and membrane blebbing.

SUBCELLULAR LOCATION

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane.

FUNCTION

Rho, the Ras-related small GTPase, is responsible for the regulation of Actin-based cytoskeletal structures including stress fibers, focal adhesions and the contractile ring apparatus. Rho proteins function as molecular switches that are able to turn cytokinesis on and off. Although little is known about signaling downstream of Rho, a host of putative Rho effector proteins have been described, including rhophilin, Rhotekin, citron and the serine/threonine kinase, protein kinase N. Two additional Rho-activated serine/threonine kinases have been described, designated Rock-1 and Rock-2 (also referred to as Roka, for Rho-associated coil-containing protein kinase). Rock-1 and Rock-2 share a structural similarity with myotonic dystrophy kinase.