Securin Recombinant Rabbit Monoclonal Antibody [JB37-37] (ET7107-50)

UNIPROT #

O95997

PROTEIN NAME

Securin

SYNONYMS

AW555095 antibody;C87862 antibody;Cut2 antibody;EAP 1 antibody;EAP1 antibody;ESP1 associated protein 1 antibody;Esp1-associated protein antibody;hPTTG antibody;MGC126883 antibody;MGC138276 antibody;Pds1 antibody;Pituitary tumor transforming 1 antibody;Pituitary tumor transforming protein 1 antibody;Pituitary tumor-transforming 1, isoform CRA_a antibody;Pituitary tumor-transforming 1, isoform CRA_b antibody;Pituitary tumor-transforming gene 1 antibody;Pituitary tumor-transforming gene 1 protein antibody;PTTG 1 antibody;PTTG antibody;PTTG1 antibody;PTTG1 protein antibody;PTTG1_HUMAN antibody;Pttg3 antibody;Securin antibody;Tumor transforming 1 antibody;Tumor transforming protein 1 antibody;Tumor-transforming protein 1 antibody;TUTR 1 antibody;TUTR1 antibody

SEQUENCE SIMILARITIES

Belongs to the securin family.

TISSUE SPECIFICITY

Expressed at low level in most tissues, except in adult testis, where it is highly expressed. Overexpressed in many patients suffering from pituitary adenomas, primary epithelial neoplasias, and esophageal cancer.

DEVELOPMENTAL STAGE

Low level during G1 and S phases. Peaks at M phase. During anaphase, it is degraded.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated at Ser-165 by CDK1 during mitosis.; Phosphorylated in vitro by ds-DNA kinase.; Ubiquitinated through 'Lys-11' linkage of ubiquitin moieties by the anaphase promoting complex (APC) at the onset of anaphase, conducting to its degradation. 'Lys-11'-linked ubiquitination is mediated by the E2 ligase UBE2C/UBCH10.

SUBCELLULAR LOCATION

Cytoplasm. Nucleus.

FUNCTION

Securin is a protein that in humans is encoded by the PTTG1 gene. The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus.