MGST1 Mouse Monoclonal Antibody [14H2] (EM1901-13)

UNIPROT #

P10620

PROTEIN NAME

MGST1

SYNONYMS

MGST1 antibody;Glutathione S transferase 12 antibody;GST12 antibody;MGST 1 antibody;MGST antibody;MGST I antibody;MGST1 antibody;MGST1_HUMAN antibody;Microsomal glutathione S-transferase 1 antibody;Microsomal GST 1 antibody;Microsomal GST-1 antibody;Microsomal GST-I antibody

SEQUENCE SIMILARITIES

Belongs to the MAPEG family.

TISSUE SPECIFICITY

Highly expressed in liver.

POST-TRANSLATIONAL MODIFICATION

Peroxynitrite induces nitration at Tyr-93 which activates the enzyme.

SUBCELLULAR LOCATION

Endoplasmic reticulum, Mitochondrion.

FUNCTION

DNA replication licensing factor MCM7 is a protein that in humans is encoded by the MCM7 gene.The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre-RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumor suppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.