ACE Recombinant Rabbit Monoclonal Antibody [JM59-32] (ET1705-36)

UNIPROT #

P12821

PROTEIN NAME

ACE

SYNONYMS

ACE 1 antibody;ACE antibody;ACE T antibody;ACE_HUMAN antibody;ACE1 antibody;Angiotensin converting enzyme somatic isoform antibody;Angiotensin converting enzyme testis specific isoform antibody;Angiotensin I converting enzyme 1 antibody;Angiotensin I converting enzyme antibody;Angiotensin I converting enzyme peptidyl dipeptidase A 1 antibody;angiotensin I converting enzyme peptidyl-dipeptidase A 1 transcript antibody;Angiotensin-converting enzyme antibody;Carboxycathepsin antibody;CD 143 antibody;CD143 antibody;CD143 antigen antibody;DCP 1 antibody;DCP antibody;DCP1 antibody;Dipeptidyl carboxypeptidase 1 antibody;Dipeptidyl carboxypeptidase I antibody;Kininase II antibody;MGC26566 antibody;MVCD3 antibody;Peptidase P antibody;Peptidyl dipeptidase A antibody;soluble form antibody;Testicular ECA antibody

SEQUENCE SIMILARITIES

Belongs to the peptidase M2 family.

TISSUE SPECIFICITY

Ubiquitously expressed, with highest levels in lung, kidney, heart, gastrointestinal system and prostate. Isoform Testis-specific is expressed in spermatocytes and adult testis.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated by CK2 on Ser-1299; which allows membrane retention.

SUBCELLULAR LOCATION

Secreted. Cell membrane. Cytoplasm.

FUNCTION

Angiotensin-converting enzyme (EC 3.4.15.1), or ACE, is a central component of the renin–angiotensin system (RAS), which controls blood pressure by regulating the volume of fluids in the body. It converts the hormone angiotensin I to the active vasoconstrictor angiotensin II. Therefore, ACE indirectly increases blood pressure by causing blood vessels to constrict. ACE inhibitors are widely used as pharmaceutical drugs for treatment of cardiovascular diseases. Other lesser known functions of ACE are degradation of bradykinin, substance P and amyloid beta-protein. ACE hydrolyzes peptides by the removal of a dipeptide from the C-terminus. Likewise it converts the inactive decapeptide angiotensin I to the octapeptide angiotensin II by removing the dipeptide His-Leu. Angiotensin II is a potent vasoconstrictor in a substrate concentration-dependent manner. Angiotensin II binds to the type 1 angiotensin II receptor (AT1), which sets off a number of actions that result in vasoconstriction and therefore increased blood pressure. ACE is also part of the kinin-kallikrein system where it degrades bradykinin, a potent vasodilator, and other vasoactive peptides. Kininase II is the same as angiotensin-converting enzyme. Thus, the same enzyme (ACE) that generates a vasoconstrictor (ANG II) also disposes of vasodilators (bradykinin).