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TSG101 Recombinant Rabbit Monoclonal Antibody [JJ0900] (ET1701-59)

Price: Regular price $385.00

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Catalog# ET1701-59

Rabbit Monoclonal to TSG101

Tested for

  • WB

  • IF-Cell

  • IF-Tissue

  • IHC-P

  • FC

Reacts with

  • Human

  • Mouse

  • Rat

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free
Knock-Out or Knock-Down validated
This product has been cited in peer reviewed publications, see list HERE

Safety datasheet

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Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

TSG101 Recombinant Rabbit Monoclonal Antibody [JJ0900] (ET1701-59)

Immunogen

Synthetic peptide within human tsg101 aa 24-73 / 390.

Host

Rabbit

Positive Control

HeLa cell lysate, K-562 cell lysate, MCF7 cell lysate, Jurkat cell lysate, C2C12 cell lysate, PC-12 cell lysate, NIH/3T3 cell lysate, mouse brain tissue lysate, rat brain tissue lysate, HeLa, NIH/3T3, PC-12, human kidney tissue, mouse colon tissue, mouse kidney tissue, human colon carcinoma tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

JJ0900

RRID

AB_3068599

APPLICATION DILUTION

  • WB

  • 1:2,000-1:5,000

  • IF-Cell

  • 1:200

  • IF-Tissue

  • 1:200-1:500

  • IHC-P

  • 1:500-1:1,000

  • FC

  • 1:1,000

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 44 kDa

Isotype

IgG

TARGET

UNIPROT #

Q99816

PROTEIN NAME

TSG101

SYNONYMS

ESCRT I complex subunit TSG101 antibody;ESCRT-I complex subunit TSG101 antibody;TS101_HUMAN antibody;TSG 10 antibody;TSG 101 antibody;TSG10 antibody;Tsg101 antibody;Tumor susceptibility gene 10 antibody;Tumor susceptibility gene 101 antibody;Tumor susceptibility gene 101 protein antibody;Tumor susceptibility protein antibody;Tumor susceptibility protein isoform 3 antibody;VPS 23 antibody;VPS23 antibody

SEQUENCE SIMILARITIES

Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.

TISSUE SPECIFICITY

Heart, brain, placenta, lung, liver, skeletal, kidney and pancreas.

POST-TRANSLATIONAL MODIFICATION

Monoubiquitinated at multiple sites by LRSAM1 and by MGRN1. Ubiquitination inactivates it, possibly by regulating its shuttling between an active membrane-bound protein and an inactive soluble form. Ubiquitination by MGRN1 requires the presence of UBE2D1.

SUBCELLULAR LOCATION

Cytoplasm, Cytoskeleton, Endosome, Membrane, Nucleus.

FUNCTION

The transformation of a normal cell to one that is malignant can result from mutations in genes that encode proteins with key regulatory functions. Examples include the retinoblastoma gene product (Rb p110), p53, VHL and APC. Using a novel cloning strategy that allows the isolation of previously uncharacterized genes encoding selectable recessive phenotypes, an additional tumor suppressor gene has been identified. This gene, termed tsg 101 for tumor susceptibility gene 101, encodes a stathmin binding domain protein. When expression of this growth inhibitory gene is blocked in NIH/3T3 cells using antisense mRNA, the cells exhibit a transformed phenotype and are tumorigenic in SL6 mice.

CITATIONS

  • Yang Fan,et al

    Engaging natural regulatory myeloid cells to restrict T-cell hyperactivation-induced liver inflammation via extracellular vesicle-mediated purine metabolism regulation

  • Zhou Liyan,et al

    Serum starvation induces cytosolic DNA trafficking via exosome and autophagy-lysosome pathway in microglia

  • Yan S, Huang Z, Chen X, et al

    Metabolic profiling of urinary exosomes for systemic lupus erythematosus discrimination based on HPL-SEC/MALDI-TOF MS

  • Yang Yutao,et al

    miR-21-loaded BMSC-derived Exosomes repair ovarian function of autoimmune premature ovarian insufficiency by targeting MSX1

  • Zhao Jing,et al

    Plasma-derived Exosomal miR-25-3p and miR-23b-3p as Predictors of Response to Chemoradiotherapy in Esophageal Squamous Cell Carcinoma

  • Xiaoli Wang,et al

    Matrix vesicles from osteoblasts promote atherosclerotic calcification

  • A protocol of carbonized on-column enrichment for urinary exosomal N-glycans profiling

  • Embryonic stem cell-derived extracellular vesicles promote the recovery of kidney injury

  • Embryonic stem cell-derived extracellular vesicles rejuvenate senescent cells and antagonize aging in mice

  • Qiusheng Chen

    In vivo multivesicular bodies and their exosomes in the absorptive cells of the zebrafish (Danio Rerio) gut

  • Yang Yutao,et al

    Mesenchymal stem cells-derived exosomes alleviate temporomandibular joint disc degeneration in temporomandibular joint disorder

  • Dong Kai,et al

    iMSC exosome delivers hsa-mir-125b-5p and strengthens acidosis resilience through suppression of Asic1 protein in cerebral ischemia-reperfusion

  • Chen Yijie,et al

    Designed Directional Growth of Ti-Metal-Organic Frameworks for Decoding Alzheimer's Disease-Specific Exosome Metabolites

  • Rongrong Li,et al

    Phosphatidylserine-mediated uptake of extracellular vesicles by hepatocytes ameliorates liver ischemia-reperfusion injury

  • Yang Rongfeng,et al

    Investigating the therapeutic effects and mechanisms of Carthamus tinctorius L.-derived nanovesicles in atherosclerosis treatment

  • Qiusheng Chen

    In Vivo Multivesicular Body and Exosome Secretion in the Intestinal Epithelial Cells of Turtles During Hibernation.

  • Zhang, R., Yang, Y., Dong, W., Lin, M., He, J., Zhang, X., Tian, T., Yang, Y., Chen, K., Lei, Q. Y., Zhang, S., Xu, Y., & Lv, L.

    D-mannose facilitates immunotherapy and radiotherapy of triple-negative breast cancer via degradation of PD-L1

  • Shen, M., Fan, X., Shen, Y., Wang, X., Wu, R., Wang, Y., Huang, C., Zhao, S., Zheng, Y., Men, R., Luo, X., & Yang, L.

    Myeloid-derived suppressor cells ameliorate liver mitochondrial damage to protect against autoimmune hepatitis by releasing small extracellular vesicles

  • Chunli Li ,et al

    Engineering extracellular vesicles derived from endothelial cells sheared by laminar flow for anti-atherosclerotic therapy through reprogramming macrophage

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