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TXNIP Recombinant Rabbit Monoclonal Antibody [JM60-35] (ET1705-72)

Price: Regular price $385.00

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Catalog# ET1705-72

Rabbit Monoclonal to TXNIP

Tested for

  • WB

  • IF-Cell

  • IF-Tissue

  • IHC-P

  • FC

Reacts with

  • Human

  • Mouse

  • Rat

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free
Knock-Out or Knock-Down validated
This product has been cited in peer reviewed publications, see list HERE

Safety datasheet

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Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

TXNIP Recombinant Rabbit Monoclonal Antibody [JM60-35] (ET1705-72)

Immunogen

Synthetic peptide within human txnip aa 50-99 / 391.

Host

Rabbit

Positive Control

HeLa cell lysate, NIH/3T3 cell lysate, PC-12 cell lysate, mouse stomach tissue lysate, mouse kidney tissue lysate, PC-12, human kidney tissue, mouse kidney tissue, rat kidney tissue, human stomach tissue, mouse esophagus tissue, mouse stomach tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

JM60-35

RRID

AB_3070602

APPLICATION DILUTION

  • WB

  • 1:1,000

  • IF-Cell

  • 1:50-1:200

  • IF-Tissue

  • 1:200-1:500

  • IHC-P

  • 1:400-1:5,000

  • FC

  • 1:1,000

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 44 kDa

Isotype

IgG

TARGET

UNIPROT #

Q9H3M7

PROTEIN NAME

TXNIP

SYNONYMS

EST01027 antibody;HHCPA78 antibody;THIF antibody;Thioredoxin binding protein 2 antibody;Thioredoxin interacting protein antibody;Thioredoxin-binding protein 2 antibody;Thioredoxin-interacting protein antibody;TXNIP antibody;TXNIP_HUMAN antibody;Upregulated by 1,25 dihydroxyvitamin D 3 antibody;VDUP1 antibody;Vitamin D3 up-regulated protein 1 antibody

SEQUENCE SIMILARITIES

Belongs to the arrestin family.

POST-TRANSLATIONAL MODIFICATION

Ubiquitinated; undergoes polyubiquitination catalyzed by ITCH resulting in proteasomal degradation.

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells.

CITATIONS

  • Yanping, D., Xiaoqing, D., Yifan, M. A., Lili, C., Jie, Z., Xinyan, L. I., & Baoping, S.

    Astragaloside IV plays a role in reducing radiation-induced liver inflammation in mice by inhibiting thioredoxin-interacting protein/nod-like receptor protein 3 signaling pathway

  • Chen Qingqiu,et al

    REDD1 knockdown ameliorates endothelial cell senescence through repressing TXNIP-mediated oxidative stress

  • Wu Wentong,et al

    Rutin attenuates ensartinib-induced hepatotoxicity by non-transcriptional regulation of TXNIP

  • Cao Xiang,et al

    MicroRNA-204-5p attenuates oxidative stress, apoptosis and inflammation by targeting TXNIP in diabetic cataract

  • Zhang, X., Zhao, S., Yuan, Q., Zhu, L., Li, F., Wang, H., Kong, D., & Hao, J.

    TXNIP, a novel key factor to cause Schwann cell dysfunction in diabetic peripheral neuropathy, under the regulation of PI3K/Akt pathway inhibition-induced DNMT1 and DNMT3a overexpression. Cell death & disease, 12(7), 642.

  • Wang Yue,et al

    Artemisinin attenuated ischemic stroke induced pyroptosis by inhibiting ROS/TXNIP/NLRP3/Caspase-1 signaling pathway

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