14-3-3 alpha+beta Recombinant Rabbit Monoclonal Antibody [SD0837] (ET1612-99)

UNIPROT #

P31946

PROTEIN NAME

14-3-3 alpha+beta

SYNONYMS

14 3 3 alpha antibody;14 3 3 protein beta/alpha antibody;14-3-3 protein beta/alpha antibody;1433B_HUMAN antibody;Brain protein 14 3 3 beta isoform antibody;GW128 antibody;HS 1 antibody;KCIP-1 antibody;KCIP1 antibody;N-terminally processed antibody;Protein 1054 antibody;Protein kinase C inhibitor protein 1 antibody;YWHAA antibody;YWHAB antibody

SEQUENCE SIMILARITIES

Belongs to the 14-3-3 family.

POST-TRANSLATIONAL MODIFICATION

The alpha, brain-specific form differs from the beta form in being phosphorylated. Phosphorylated on Ser-60 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion.

SUBCELLULAR LOCATION

Cytoplasm, Melanosome.

FUNCTION

14-3-3 protein beta/alpha is a protein that in humans is encoded by the YWHAB gene. This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene.